Jonathan Synnott

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PURPOSE Lesion volume is often used as an end point in clinical trials of oncology therapy. We sought to compare the common method of using orthogonal diameters to estimate lesion volume (the diameter method) with a computer-assisted planimetric technique (the perimeter method). METHODS Radiologists reviewed 825 magnetic resonance imaging studies from 219(More)
The availability of datasets capturing the performance of activities of daily living is limited by difficulties associated with the collection of such data. Software solutions can mitigate these limitations, providing researchers with the ability to rapidly generate simulated data. This paper describes the use of IE Sim to create a simulated intelligent(More)
Herein we describe the changes in the gene expression profile of Candida parapsilosis associated with the acquisition of experimentally induced resistance to azole antifungal drugs. Three resistant strains of C. parapsilosis were obtained following prolonged in vitro exposure of a susceptible clinical isolate to constant concentrations of fluconazole,(More)
Development, testing and validation of algorithms for smart home applications are often complex, expensive and tedious processes. Research on simulation of resident activity patterns in Smart Homes is an active research area and facilitates development of algorithms of smart home applications. However, the simulation of passive infrared (PIR) sensors is(More)
Current clinical methods for the assessment of Parkinson's disease (PD) suffer from inconvenience, infrequency, and subjectivity. WiiPD is an approach for the objective home-based assessment of PD which utilizes the intuitive and sensor-rich Nintendo Wii remote. Combined with an electronic patient diary, a suite of minigames, a metric analyzer, and a(More)
The development, testing and evaluation of novel approaches to Intelligent Environment data processing require access to datasets which are of high quality, validated and annotated. Access to such datasets is limited due to issues including cost, flexibility, practicality, and a lack of a globally standardized data format. These limitations are detrimental(More)
This paper introduces WiiPD, an approach to home-based objective assessment of Parkinson's disease. WiiPD aims to make use of the many capabilities of the Nintendo Wii Remote in combination with a number of bespoke data gathering methods to provide a rich and engaging user experience that can capture a wide range of motor and non-motor metrics. In this(More)