Jonathan Stoehr

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Inflammatory processes may play a critical role in the pathogenesis of the degenerative changes and cognitive impairments associated with Alzheimer's disease (AD). In the present study, lipopolysaccharide (LPS) from the cell wall of gram-negative bacteria was used to produce chronic, global inflammation within the brain of young rats. Chronic infusion of(More)
The behavioral, biochemical, histological, and electrophysiological effects of a basal forebrain injection of saporin, a ribosome-inactivating protein, coupled to a monoclonal antibody against the low-affinity NGF receptor (192 IgG) were investigated in adult rats. Within the basal forebrain region, the low-affinity NGF receptor is exclusively expressed by(More)
BACKGROUND Syncopal episodes are common among older adults; etiologies range from benign to life threatening. We determined the frequency, yield, and costs of tests obtained to evaluate older persons with syncope. We also calculated the cost per test yield and determined whether the San Francisco syncope rule (SFSR) improved test yield. METHODS Review of(More)
The effects of selective cholinergic cell loss within the basal forebrain (BF) were determined using a task that requires shifting of attention between two visual stimuli. Discriminability between two stimuli and response bias were determined in young and old F-344 rats given BF injections of IgG-192 saporin (100 ng). The lesion reduced ChAT activity in the(More)
Glutamate may act via an N-methyl-D-Aspartate (NMDA)-sensitive receptor site to destroy cholinergic neurons within the nucleus basalis magnocellularis in age-associated neurodegenerative diseases. Multiple interesting properties of the NMDA receptor are relevant to its excitotoxic actions, e.g., glutamate is ineffective unless a glycine (gly) modulatory(More)
BACKGROUND Cognitive, global and functional instruments have been extensively investigated for correlations with neuropathological changes such as neurofibrillary tangles (NFTs), plaques, and synapse loss in the brain. OBJECTIVE Our objective is to correlate the functional, global and cognitive decline assessed clinically with the neuropathological(More)
The present study investigated the effects of nucleus basalis magnocellularis (NBM) lesions in young (3 months), adult (9 months), and aged (24 months) rats by injections of either NMDA or AMPA upon performance of a delayed alternation task on a T maze. During phase 1 of testing, the interchoice interval (ICI) was 5 s and each rat was given 10 trials per(More)
Antidepressant medications are commonly prescribed for older adults with depressive symptoms who may not have a major depressive disorder. Yet the effect of antidepressants on depressive symptoms in this population over time is largely unknown. We sought to determine whether the use of antidepressant medications is associated with a reduction in the(More)
Single glucose doses of 0.5 g/kg body weight or 1.0 g/kg were intravenously applied at ambient temperatures between 25 degrees C and 30 degrees C pigs aged between zero and 20 hours two and three, five and seven, ten and 14, 20 and 30 days, and eight weeks. With reference to excess glucose curves in the blood and plasma, the half-life of glucose elimination(More)
Fructose tolerance tests were applied to 54 piglets, aged between zero and 20 hours, two and three, five and seven, as well as 20 and 30 days. Fructose injections per kilogram of body weight were 0.5 g and 1.0 g. Galactose tolerance tests were applied to 33 piglets, aged between zero and 20 hours as well as between five and seven or 20 and 35 days. The(More)
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