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and anonymous referees for helpful comments and discussions, and Jonathan Adams and Caroline Weber for invaluable research assistance. Financial support from NSF Grant SES-0134946 is gratefully acknowledged. The views expressed herein are those of the author(s) and do not necessarily reflect the views of the National Bureau of Economic Research. ABSTRACT(More)
In this paper, we developed and compared several expectation-maximization (EM) algorithms to find maximum likelihood estimates of individual inbreeding coefficients using molecular marker information. The first method estimates the inbreeding coefficient for a single individual and assumes that allele frequencies are known without error. The second method(More)
Reuse distance (i.e. LRU stack distance) precisely characterizes program locality and has been a basic tool for memory system research since the 1970s. However, the high cost of measuring has restricted its practical uses in performance debugging, locality analysis and optimizations of long-running applications.In this work, we improve the efficiency by(More)
OBJECTIVE To study the effect of interleukin-2 receptor monoclonal antibodies on acute rejection episodes, graft loss, deaths, and rate of infection and malignancy in patients with renal transplants. DESIGN Meta-analysis of published data. DATA SOURCES Medline, Embase, and Cochrane library for years 1996-2003 plus search of medical editors' trial(More)
Peripheral neuropathy is a major consequence of diabetes mellitus with up to 50 % of patients showing clinically significant neural injury during the disease course. Hearing loss (as defined by impaired sound detection thresholds) is a recognized symptom of DM, but the possibility of auditory neuropathy (AN) has not been explored in this population. This(More)
OBJECTIVE To quantify the risk for type 2 diabetes by body habitus measurements among remote-living Australian Aborigines relative to that measured in the general Australian population (as characterized by the Australian Diabetes, Obesity and Lifestyle [AusDiab] study). RESEARCH DESIGN AND METHODS Anthropometric measurements and diabetes status were(More)