Jonathan Shanks

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Fanconi anaemia (FA) is an inherited disease with congenital and developmental abnormalities characterised by cellular cross linker hypersensitivity. FA is caused by mutations in any of so far 15 identified FANC genes, which encode proteins that interact in a common DNA damage response (DDR) pathway. Individuals with FA have a high risk of developing acute(More)
Surgery for cancer of the floor of the mouth often results in alteration of the muscles of the tongue and floor of the mouth. Both primary and secondary surgical procedures often result in scar formation with reduced mobility of the tongue during speech and deglutition. Speech is often used as a diagnostic tool in the placement of the anterior teeth during(More)
BACKGROUND VEGF-targeted therapy has become the mainstay of treatment for majority of mRCC patients. For most patients, benefit is short-lived and therefore treatment remains palliative in intent. HD IL2 is an effective immunotherapy treatment capable of durable remission in some patients but its unselected use has been difficult due to its modest response(More)
A family is described in which a girl, two boys and their father showed speech hypernasality. A half-sib, a grandfather, a great-aunt, and a cousin of these sibs also showed a similar speech defect. Analysis of recorded speech of the father and three sibs revealed articulation deficiencies in addition to hypernasality. Intra-oral examination and neurologic(More)
Measurements of velopharyngeal gaps were obtained for 110 subjects with suspected velopharyngeal incompetence. Cephalometric x rays during a high vowel, /i/, and a sustained voiceless sibilant, /s/, were compared. Velopharyngeal gaps for the two phonemes differed in group means and for most individual subjects, with greater gaps being found for /i/ than for(More)
A dichotic CV-syllable listening task was administered to a group of eleven non-brain-injured adults and to a group of eleven adult aphasics. The results of this study may be summarized as follows: 1)The group of non-brain-injured adults showed a slight right ear advantage for dichotically presented CV-syllables. 2)In comparison with the control group the(More)
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