Jonathan Robertson

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Current treatments of neuropathic pain arising from conditions such as nerve injury/compression are only partially effective, and limited in their use by side-effects. p38 mitogen-activated protein kinase (MAPK) is involved in the regulation and synthesis of inflammatory mediators, and is the target for a novel class of cytokine-suppressive(More)
1. Patients should be divided preoperatively into low- or high-risk categories, depending on their probability of developing postoperative pulmonary complications. The evaluation should include spirometry as well as an assessment of the previously defined risk factors. 2. Patients in a low-risk category need only instruction in deep breathing pre- and(More)
OBJECTIVE The objective was to compare the pharmacokinetics of sumatriptan and naproxen in adolescent migraineurs and healthy adults after administration of sumatriptan/naproxen sodium combination tablets. DESIGN The design was an open-label, randomized, parallel group study. Adolescent migraineurs (12-17 years) and healthy adults received 1 dose of(More)
AIMS Endothelial-derived epoxyeicosatrienoic acids may regulate vascular tone and are metabolized by soluble epoxide hydrolase enzymes (sEH). GSK2256294 is a potent and selective sEH inhibitor that was tested in two phase I studies. METHODS Single escalating doses of GSK2256294 2-20 mg or placebo were administered in a randomized crossover design to(More)
STUDY OBJECTIVES Investigate the hypnotic effects of repeated doses of neurokinin-1 receptor antagonist, vestipitant, in primary insomnia. DESIGN Randomized, double-blind, placebo-controlled 28-day parallel-group study. SETTING Eleven sleep centers in Germany. PATIENTS One hundred sixty-one patients with primary insomnia. INTERVENTIONS Patients(More)
3D game development is an exciting activity for many students. But getting a handle on 3D game development for novices may be a daunting task. We take this opportunity to present a quick introduction to 3D game development through a few tutorials. For the next few columns a set of tutorials for a 3D first person shooter game developed by graduate and(More)
Topical corticosteroids remain the first-line therapy for atopic dermatitis (AD). Hence, we investigated the efficacy and safety profile of a novel selective corticosteroid, GW870086. We performed 2 randomised, double-blind, controlled studies with 25 AD patients and 20 healthy subjects. The changes in the Three-Item Severity (TIS) score and the skin(More)
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