Jonathan R. Keller

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Understanding and harnessing cellular potency are fundamental in biology and are also critical to the future therapeutic use of stem cells. Transcriptome analysis of these pluripotent cells is a first step towards such goals. Starting with sources that include oocytes, blastocysts, and embryonic and adult stem cells, we obtained 249,200 high-quality EST(More)
The University of South Carolina is currently implementing the procedure presented in the publication " Integration of Maintenance Management Systems and Health Monitoring Systems through Historical Data Investigation. " This particular application is attempting to merge TAMMS-A records with data collected from Intelligent Automation Corporation's Vibration(More)
(1174 articles) Red Cells (4939 articles) Immunobiology (3094 articles) Hematopoiesis and Stem Cells Articles on similar topics can be found in the following Blood collections Information about subscriptions and ASH membership may be found online at: digital object identifier (DOIs) and date of initial publication. the indexed by PubMed from initial(More)
Maintenance Management Systems (MMS) are the core of traditional maintenance record-keeping practices and often facilitate the usage of textual descriptions of faults and actions performed on a vehicle. Recently developed Health and Usage Monitoring Systems (HUMS) are capable of directly monitoring vehicle component parameters; however, attempts to link(More)
Our fourth component of research is focusing on expanding the Cost and Benefit Analysis (CBA) has been carried out to reflect on the whole CBM roadmap. This includes the cost savings in parts cost, operational support, the increase in mission capability rates, the decrease in scheduled and non-scheduled maintenance, and the increase in total flight time. It(More)
Transforming growth factor beta (TGF-beta) acts as a potent inhibitor of the growth and functions of lymphoid and hemopoietic progenitor cells. Cell proliferation depends not only on the presence of growth factors, but also on the development of specific receptor-signal transducing complexes. We therefore investigated whether the inhibitory actions of(More)
  • Abdel Bayoumi, Nicholas Goodman, Ronak Shah, Trevor Roebuck, Andrew Jarvie, Les Eisner +2 others
  • 2008
One of the most expensive and time consuming tasks relating to Condition Based Maintenance involves the testing of mechanical components for CBM. A scientific plan is being developed to identify components that will return the most value within a short time for implementation of CBM. This plan is also based on the historical (TAMMS-A and VMU) data that we(More)
Toll-like receptor 4 (Tlr4) has a pivotal role in innate immune responses, and the transcription factor CCAAT/enhancer binding protein delta (C/EBPδ, Cebpd) is a Tlr4-induced gene. Here we identify a positive feedback loop in which C/EBPδ activates Tlr4 gene expression in macrophages and tumour cells. In addition, we discovered a negative feedback loop(More)
Transforming growth factor beta 1 (TGF-beta 1) has been shown to be associated with active centers of hematopoiesis and lymphopoiesis in the developing fetus. Therefore, the effects of TGF-beta 1 on mouse hematopoiesis were studied. TGF-beta 1 is a potent inhibitor of IL-3-induced bone marrow proliferation, but it does not inhibit the proliferation induced(More)
IL-7 administration to mice was previously reported to increase the mobilization of progenitor cells from marrow to peripheral sites. We now report that IL-7 increases the number of mature myeloid and monocytic cells in spleen and peripheral blood. This effect required T cells, and we show that IL-7 treatment in vivo induced GM-CSF and IL-3 production by T(More)