Jonathan N. Wells

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It is an exciting time for protein design and engineering. In addition to establishing fundamental guidelines for the manipulation of protein structure and stability, several groups have begun to both successfully manipulate the properties of therapeutically important proteins and design proteins that display novel ligand-binding and catalytic activities.(More)
The assembly of heteromeric protein complexes is an inherently stochastic process in which multiple genes are expressed separately into proteins, which must then somehow find each other within the cell. Here, we considered one of the ways by which prokaryotic organisms have attempted to maximize the efficiency of protein complex assembly: the organization(More)
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