Jonathan M. Kaye

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Acute hypercapnia was studied to assess its potential as a noninvasive and simple test for evoking neuroendocrine, cardiovascular and psychological responses to stress in man. A single breath of four concentrations of carbon dioxide (CO(2)), 5%, 25%, 35% and 50%, was administered to nine healthy volunteers in a randomized, single-blind fashion. Although no(More)
In producing realistic, animatable models of the human body, we see much to be gained from developing a functional anatomy that links the anatomical and physiological behavior of the body through fundamental causal principles. This paper describes our current Finite Element Method implementation of a simplified lung and chest cavity during normal quiet(More)
The MediSim system extends virtual environments (both local and network) to represent simulated medical personnel interacting with simulated casualties. Our technology fosters dual-use applications involving planning, training, and evaluation of both medical corpsmen and civilian EMTs. Behaviors and behavioral control are being developed for the medical(More)
We have developed a computer system for modeling mechanical physiological behavior in an interactive, 3D virtual environment. Such an environment can be used to facilitate exploration of cardiopul-monary physiology, particularly in situations that are diicult to reproduce clinically. We integrate 3D deformable body dynamics with new, formal models of(More)
We have developed a real-time computer system for modeling mechanical physiological behavior in an interactive, 3-D virtual environment. Such an environment can be used to facilitate exploration of cardiopulmonary physiology, particularly in situations that are difficult to reproduce clinically. We integrate 3-D deformable body dynamics with new, formal(More)
there has been an explosive growth of multimedia software designed to enliven presentation of medical topics through computer animations, actual videos of patients, and quantitative patient models. However, we have yet to see programs that combine sophisticated physiological models, such as those developed in the bioengineering literature, with 3D anatomy(More)
Injuries in trauma aaect anatomical structures and indirectly aaect physiological systems through mechanical behavior and physical proximity. This paper presents our methods and models for simulation cardiopulmonary anatomy and physiology. We demonstrate our system that simulates normal, quiet breathing, and a tension pneumoth-orax. Our goal is to enable(More)
This document describes a sizable grammar of English written in the TAG formalism and im plemented for use with the XTAG system This report and the grammar described herein supersedes the TAG grammar described in Abeill e et al The English grammar de scribed in this report is based on the TAG formalism developed in Joshi et al which has been extended to(More)
OBJECTIVE Glucocorticoids play an essential role in the neuroendocrine response to stress, influencing both the hypothalamic-pituitary-adrenal (HPA) axis and the sympatho-adrenomedullary (SAM) axis at several levels. In this pilot study, a clinical model of primary adrenocortical failure (Addison's disease, AD) has been used to evaluate the role of(More)