Jonathan M. Holmes

Learn More
OBJECTIVE To evaluate the reliability of a new visual acuity testing protocol for children using isolated surrounded HOTV optotypes. METHODS After initial pilot testing and modification, the protocol was evaluated using the Baylor-Video Acuity Tester (BVAT) to present isolated surrounded HOTV optotypes. At 6 sites, the protocol was evaluated for(More)
PURPOSE We developed a near ocular dominance test modeled after the distance hole-in-the-card test and assessed both test-retest reliability of four tests of ocular dominance and agreement between tests. METHODS Forty-six subjects aged 18 to 78 years with visual acuity 20/40 or better in each eye were enrolled from a primary care practice. All subjects(More)
PURPOSE To assess the test-retest reliability of the electronic Early Treatment Diabetic Retinopathy Study (E-ETDRS) visual acuity algorithm using the computerized Electronic Visual Acuity (EVA) tester in children 7 to <13 years old. DESIGN Test-retest reliability study. METHODS This multicenter study involved 245 subjects at four clinical sites. As the(More)
PURPOSE To determine the effect of induced monocular blur on stereoacuity measured with real depth and random dot tests. METHODS Monocular visual acuity deficits (range, 20/15 to 20/1600) were induced with 7 different Bangerter filters (<0.1, 0.1, 0.2, 0.3, 0.4, 0.8, and 1.0) in 15 visually normal adults. Stereoacuity was measured with Frisby and Frisby(More)
PURPOSE To determine factors associated with pretreatment and posttreatment stereoacuity in subjects with moderate anisometropic amblyopia. METHODS Data for subjects enrolled in seven studies conducted by the Pediatric Eye Disease Investigator Group were pooled. The sample included 633 subjects aged 3 to <18 years with anisometropic amblyopia, no(More)
BACKGROUND We prospectively evaluated the performance of three stereoacuity tests in patients with a wide range of strabismus angles to determine the maximum angle of horizontal strabismus consistent with true stereopsis as well as the extent of false-positive results. METHODS Subjects age > or = 5 years old (n = 186) with constant horizontal strabismus(More)
PURPOSE To develop a presentation protocol for the new Frisby-Davis 2 (FD2) distance stereoacuity test. DESIGN Prospective data collection. METHODS Stereoacuity was tested monocularly and binocularly in 95 patients with a variety of strabismic and nonstrabismic conditions, using the FD2, employing a modified staircase procedure. The Preschool Randot(More)
Antigens and infectious agents that stimulate interferon alpha(IFN-alpha) production in mice induce antibody responses that are predominantly of the immunoglobulin (Ig)G2a isotype and contain little or no IgE. This suggested the possibility that IFN-alpha might have a role in directing Ig isotype selection. Consistent with this possibility, we have found(More)
PURPOSE The method of counting cell nuclei above the internal limiting membrane in histologic sections is considered the standard when quantifying neovascularization (NV) in rodent oxygen-induced retinopathy (OIR). An alternative, more rapid method of counting clock hours in flatmounted adenosine diphosphatase (ADPase)-stained rat retinas is analogous to(More)
In vivo experiments were performed to determine whether the cross-linking of membrane immunoglobulin (mIg) D on mature B cells, in the absence of T cell help, leads to B cell death. Mice were injected with either a monoclonal antibody (mAb) that cross-links mIgD effectively or a mAb that binds to mIgD avidly but cross-links it to a limited extent, and(More)