Jonathan M. Cooper

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A novel microelectronic "pill" has been developed for in situ studies of the gastro-intestinal tract, combining microsensors and integrated circuits with system-level integration technology. The measurement parameters include real-time remote recording of temperature, pH, conductivity, and dissolved oxygen. The unit comprises an outer biocompatible capsule(More)
Ultrasonics offers the possibility of developing sophisticated fluid manipulation tools in lab-on-a-chip technologies. Here we demonstrate the ability to shape ultrasonic fields by using phononic lattices, patterned on a disposable chip, to carry out the complex sequence of fluidic manipulations required to detect the rodent malaria parasite Plasmodium(More)
Two phase microfluidic systems creating size-controlled microdroplets have recently emerged as powerful tools to achieve liquid compartmentalization for high throughput chemical and biological assays. Emulsion electrocoalescence is a destabilization process that can be used in droplet-based platforms for water phase separation to enable lab-on-a-chip(More)
This paper describes the implementation of a sensitive, on-chip immunoassay for the analysis of intracellular proteins, developed using microdroplet technology. The system offers a number of analytical functionalities, enabling the lysis of low cell numbers, as well as protein detection and quantification, integrated within a single process flow. Cells were(More)
Electrocoalescence of water-in-oil microdroplets in microfluidic channels is an active technique that enables droplet-based mixing functionalities to be achieved in lab-on-a-chip applications. In this work, a characterization of the electrocoalescence mechanisms of water microdroplets in oil is presented, using localized electric field systems. We report a(More)
Stem cells hold great promise as a means of treating otherwise incurable, degenerative diseases due to their ability both to self-renew and differentiate. However, stem cell damage can also play a role in the disease with the formation of solid tumors and leukaemias such as chronic myeloid leukaemia (CML), a hematopoietic stem cell (HSC) disorder. Despite(More)
A telemetry microsystem, including multiple sensors, integrated instrumentation and a wireless interface has been implemented. We have employed a methodology akin to that for System-on-Chip microelectronics to design an integrated circuit instrument containing several "intellectual property" blocks that will enable convenient reuse of modules in future(More)
Current strategies for cell-based screening generally focus on the development of highly specific assays, which require an understanding of the nature of the signaling molecules and cellular pathways involved. In contrast, changes in temperature of cells provides a measure of altered cellular metabolism that is not stimulus specific and hence could have(More)
There is a continued interest in the development of new on-chip protocols for the determination of the causes of infectious disease. In this paper, we demonstrate the use of surface-enhanced resonance Raman scattering (SERRS) for detecting the clinically relevant nucleic acid sequences of Chlamydia trachomatis in a bead-based lab-on-a-chip format,(More)
Boundary walls in microfluidic devices have a strong influence on the fluid flow and drag forces on moving objects. The Stokes drag force acting on a sphere translating in the fluid is increased by the presence of a neighboring wall by a factor given by Faxén's correction. A similar increase in the rotational drag is expected when spinning close to a wall.(More)