Jonathan Leor

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UNLABELLED Restenosis following coronary angioplasty represents a major clinical problem. Irreversible electroporation (IRE) is a nonthermal, nonpharmacological cell ablation method. IRE utilizes a sequence of electrical pulses that produce permanent damage to tissue within a few seconds. METHODS AND RESULTS The left carotid arteries of eight rats(More)
BACKGROUND Diabetic patients present with an accelerated atherosclerotic process and an increased risk for future cardiovascular events. In addition to the risk imposed by the disease itself, pharmacological treatment adds also a sizable risk, especially if certain classes of antidiabetic drugs are employed. Animal evidence indicates that dipeptidyl(More)
BACKGROUND The neonatal heart possesses the unique power to regenerate in response to resection of the left ventricular apex. We sought to determine whether the type of injury affects the mode of repair and regeneration. METHODS AND RESULTS Apical resection, or permanent left anterior descending coronary artery ligation, was induced in neonatal 1-day-old(More)
BACKGROUND Human mesenchymal stromal cells (hMSCs) from adipose cardiac tissue have attracted considerable interest in regard to cell-based therapies. We aimed to test the hypothesis that hMSCs from the heart and epicardial fat would be better cells for infarct repair. METHODS AND RESULTS We isolated and grew hMSCs from patients with ischemic heart(More)
BACKGROUND Irreversible electroporation (IRE) is a non-thermal cell ablation approach that induces selective damage to cell membranes only. The purpose of the current study was to evaluate and optimize its use for in-vivo myocardial decellularization. METHODS Forty-two Sprague-Dawley rats were used to compare myocardial damage of seven different IRE(More)
BACKGROUND Erythropoietin possesses cellular protection properties. The aim of the present study was to test the hypothesis that in situ expression of recombinant human erythropoietin (rhEPO) would improve tissue repair in rat after myocardial infarction (MI). METHODS AND RESULTS RhEPO-producing cardiac fibroblasts were generated ex vivo by transduction(More)
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