Jonathan Kay

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BACKGROUND PATIENTS with rheumatoid arthritis (RA) are at increased risk of developing comorbid conditions. OBJECTIVES To evaluate the prevalence of comorbidities and compare their management in RA patients from different countries worldwide. METHODS STUDY DESIGN international, cross-sectional. PATIENTS consecutive RA patients. DATA COLLECTED(More)
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mtDNA are unclear. In this study, we analyzed somatic alterations in mtDNA from 1675 tumors. We identified 1907 somatic(More)
Networking software is a growing bottleneck in modern workstations, particularly for high throughput applications such as networked digital video. We measure various components of the UDP/IP protocol stack in a DECstation 5000/200 running Ultrix 4.2a, and quantify the way in which checksumming and copying dominate the processing time for high throughput(More)
OBJECTIVES The ALIGN study (NCT01061723) evaluated the efficacy and safety of sarilumab, the first fully human monoclonal antibody against interleukin-6 receptor-α (IL-6Rα), in patients with ankylosing spondylitis (AS). METHODS Patients with active AS despite conventional treatment were randomised to placebo, or one of five subcutaneous dose regimens of(More)
Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of three men. Mutations were present at high levels in morphologically normal tissue distant from the cancer, reflecting clonal expansions, and the underlying mutational processes at work(More)
OBJECTIVE The aim of this study was to assess long-term golimumab therapy in patients with rheumatoid arthritis (RA) who discontinued previous tumour necrosis factor alpha (TNFα) inhibitor(s) for any reason. METHODS Results through week 24 of this multicentre, randomised, double-blind, placebo-controlled study of active RA (≥4 tender, ≥4 swollen joints)(More)
INTRODUCTION Clinical trials of new treatments for rheumatoid arthritis (RA) typically require subjects to have an elevated acute phase reactant (APR), in addition to tender and swollen joints. However, despite the elevation of individual components of the Clinical Disease Activity Index (CDAI) (tender and swollen joint counts and patient and physician(More)
This paper presents detailed measurements of processing overheads for the Ultrix 4.2a implementation of TCP/IP network software running on a DECstation 5000/200. The performance results were used to unco ver throughput and latency bottlenecks. We present a scheme for impro ving throughput when sending large messages by a voiding most checksum computations(More)
OBJECTIVE To assess pooled golimumab safety up to year 3 of rheumatoid arthritis (RA), psoriatic arthritis (PsA) and ankylosing spondylitis (AS) trials. METHODS Golimumab 50 and 100 mg, administered subcutaneously (SC) every 4 weeks (q4wk), were assessed in patients with active RA (methotrexate-naïve, methotrexate-experienced and anti-TNF (tumour necrosis(More)
  • Gilberto Castañeda-Hernández, Rodrigo González-Ramírez, Jonathan Kay, Morton A Scheinberg
  • 2015
Biosimilars are now a reality in rheumatology. Although analytical and non-clinical procedures to establish similarity have evolved significantly, clinical trials demonstrating equivalent efficacy and safety are absolutely required for all biosimilars. The design of such trials, including equivalence and non-inferiority statistical approaches, are(More)