Jonathan K. Smith

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BACKGROUND Although many studies of painful rectal stimulation have found activation in the insula, cingulate, somatosensory, prefrontal cortices and thalamus, there is considerable variability when comparing functional magnetic resonance imaging (fMRI) results. Multiple factors may be responsible, including the model used in fMRI data analysis. Here, we(More)
BACKGROUND   Recurrent abdominal pain is reported by a third of patients with diverticulosis, particularly those with previous episodes of acute diverticulitis. The current understanding of the etiology of this pain is poor. Our aim was to assess visceral sensitivity in patients with diverticular disease and its association with markers of previous(More)
• 9 young adults; mean age: 23y. • Subjects viewed radial checkerboard stimuli presented at fixation for 500ms. Stimuli were presented singly or in a pair separated by 2s SOA. • Subjects detected infrequent presentation of a white surround. • Analyses • Iterative correlation analysis: canonical waveform used to generate functional ROIs in pericalcarine(More)
BACKGROUND The relative importance of peripheral nerve injury or central pain processing in painful diverticular disease (DD) is unclear. Functional magnetic resonance imaging (fMRI) has demonstrated that dysfunctional central pain processing predominates in irritable bowel syndrome (IBS). This study aims to identify anticipatory changes in symptomatic DD(More)
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