Jonathan J. Miner

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In inflamed venules, leukocytes use P-selectin glycoprotein ligand-1 (PSGL-1) to roll on P-selectin and E-selectin and to activate integrin alphaLbeta2 (lymphocyte function-associated antigen-1, LFA-1) to slow rolling on intercellular adhesion molecule-1 (ICAM-1). Studies in cell lines have suggested that PSGL-1 requires its cytoplasmic domain to localize(More)
Leukocytes roll on P-selectin after its mobilization from secretory granules to the surfaces of platelets and endothelial cells. Tumor necrosis factor (TNF), IL-1β, and lipopolysaccharide increase synthesis of P-selectin in murine but not in human endothelial cells. To explore the physiological significance of this difference in gene regulation, we made(More)
BACKGROUND Increasing evidence elucidating the pathogenic mechanisms of ulcerative colitis (UC) has accumulated and the disease is widely assumed to be the consequence of genetic susceptibility and an abnormal immune response to commensal bacteria. However evidence regarding an infectious etiology in UC remains elusive. CASE PRESENTATION We report a(More)
  • Cathy Day, Jennifer Alix-Garcia, +8 authors Mark Poffenberger
  • 2011
Ethnic Brao wood resin tree (Dipterocarpus alatus) tapper from Taveng District, Ratanakiri Province, northeastern Cambodia. 2002 Ugandan lakeshore. Acknowledgments We would first like to thank the case study authors for sharing their important insights and wisdom gained from their innovative fieldwork and analyses. We also and Kelly Wendland (Univ. Idaho)(More)
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