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Quantum dot (QD) labeling combined with fluorescence lifetime imaging microscopy is proposed as a powerful transduction technique for the detection of DNA hybridization events. Fluorescence lifetime analysis of DNA microarray spots of hybridized QD labeled target indicated a characteristic lifetime value of 18.8 ns, compared to 13.3 ns obtained for spots of(More)
Machine learning and statistical model based classifiers have increasingly been used with more complex and high dimensional biological data obtained from high-throughput technologies. Understanding the impact of various factors associated with large and complex microarray datasets on the predictive performance of classifiers is computationally intensive,(More)
This paper reviews the work carried out in the field of reconfigurable antennas, and in specific the reconfigurable MEMS (Micro-Electro-Mechanical Systems) antennas. The application of MEMS to antennas is studied and compared with the various implementations such as pattern reconfigurable MEMS antennas, mechanically actuated MEMS antennas, capacitive MEMS(More)
This paper outlines the systematic production and characterisation of biocompatible square microfabricated electrode systems for electroanalysis. In contrast to previous results, a combination of simulation, theoretical analysis and measurement has established that there is an enhanced current density for a microsquare electrode under mass transport(More)
General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy The University of Edinburgh has made every(More)
The performance of two electrode architectures with broadly similar overall active electrode areas are examined. The first is an electrode comprising a single contiguous area (a disc) and the second is an electrode in which the cumulative electrode area is dispersed over a wide area as a 50 nm thickness platinum nanoband. A direct comparison of the(More)
Micron resolution photolithography has been employed to make microsquare nanoband edge electrode (MNEE) arrays with reproducible and systematic control of the crucial dimensional parameters, including array element size and spacing and nanoelectrode thickness. The response of these arrays, which can be reproducibly fabricated on a commercial scale, is first(More)
DNA nanoswitches can be designed to detect unlabelled nucleic acid targets and have been shown to discriminate between targets which differ in the identity of only one base. This paper demonstrates that the fluorescent base analogue 2-aminopurine (AP) can be used to discriminate between nanoswitches with and without targets and to discriminate between(More)
Definitional and conceptual issues related to the symptoms of impulsivity, irritability, and depression are described. A brief overview of the relevant neurobiology of each symptom is then provided. General psychopharmacologic strategies to address these symptoms are explored. Finally, brief clinical vignettes are described along with specific pharmacologic(More)
The manipulation of ribosomal RNA (rRNA) extracted from E. coli cells by dielectrophoresis (DEP) has been demonstrated over the range of 3 kHz-50 MHz using interdigitated microelectrodes. Quantitative measurement using total internal reflection fluorescence microscopy of the time dependent collection indicated a positive DEP response characterized by a(More)
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