Jonathan G McEuen

Learn More
Stress is a common trigger in affective disorder onset, yet the mechanism and predisposing factors of vulnerability remain unknown. Effective disease prevention requires a critical balance of responses within the serotonergic raphe nucleus, including a coordination of corticotropin-releasing factor (CRF) actions at both of its receptors, CRF receptor-1 and(More)
Traditional detection of drugs in tissue requires tissue homogenization, which precludes the mapping and localization of drugs. The use of autoradiography could compensate for such shortcoming. However, it requires expensive custom-synthesized radioactive drugs. Recent improvement in sample preparation for matrix-assisted laser desorption/ionization mass(More)
Stress sensitivity and sex are predictive factors in affective disorder susceptibility. Serotonin (5-HT) pathway recruitment by corticotropin-releasing factor (CRF) during stress is necessary in adaptive coping behaviors, but sex differences in such responses have not been investigated. Using selective 5-HT reuptake inhibitor (SSRI) administration to(More)
Introduction The objective of this research has been to develop and test a theoretical framework in which words in the lexicon are represented as sequences of segments and the segments are represented, in part, as auditory goals. Control mechanisms for the production of speech sound sequences are based on the auditory goals, which, for the present purposes,(More)
Introduction The objective of this research is to refine and test a theoretical framework in which words in the lexicon are represented as sequences of segments and syllables and these units are represented as complexes of auditory/acoustic and somatosensory goals. The motor programming to produce sequences of sensory goals utilizes an internal neural model(More)
  • 1