Jonathan E Sevransky

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OBJECTIVE To provide an update to the original Surviving Sepsis Campaign clinical management guidelines, "Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock," published in 2004. DESIGN Modified Delphi method with a consensus conference of 55 international experts, several subsequent meetings of subgroups and key(More)
Objective: To provide an update to the " Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock, " last published in 2008. Design: A consensus committee of 68 international experts representing 30 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members(More)
RATIONALE Accurate, early identification of patients at risk for developing acute lung injury (ALI) provides the opportunity to test and implement secondary prevention strategies. OBJECTIVES To determine the frequency and outcome of ALI development in patients at risk and validate a lung injury prediction score (LIPS). METHODS In this prospective(More)
Acute Lung Injury (ALI) is a syndrome with high associated mortality characterized by severe hypoxemia and pulmonary infiltrates in patients with critical illness. We conducted the first investigation to use the genome wide association (GWA) approach to identify putative risk variants for ALI. Genome wide genotyping was performed using the Illumina Human(More)
OBJECTIVE To evaluate the association of volume limited and pressure limited (lung protective) mechanical ventilation with two year survival in patients with acute lung injury. DESIGN Prospective cohort study. SETTING 13 intensive care units at four hospitals in Baltimore, Maryland, USA. PARTICIPANTS 485 consecutive mechanically ventilated patients(More)
INTRODUCTION The short-term mortality benefit of lower tidal volume ventilation (LTVV) for patients with acute lung injury/acute respiratory distress syndrome (ALI/ARDS) has been demonstrated in a large, multi-center randomized trial. However, the impact of LTVV and other critical care therapies on the longer-term outcomes of ALI/ARDS survivors remains(More)
The genetic basis of acute lung injury (ALI) is poorly understood. The myosin light chain kinase (MYLK) gene encodes the nonmuscle myosin light chain kinase isoform, a multifunctional protein involved in the inflammatory response (apoptosis, vascular permeability, leukocyte diapedesis). To examine MYLK as a novel candidate gene in sepsis-associated ALI, we(More)
Objectif : Apporter une mise à jour au guide de la campagne « Surviving Sepsis » (Survivre au sepsis) pour la prise en charge du sepsis sévère et du choc septique, publié pour la dernière fois en 2008. Description : Un comité consensuel de 68 experts internationaux représentant 30 organisations internationales a été formé. Des groupes nominaux ont été(More)
INTRODUCTION Patients with sepsis suffer high morbidity and mortality. We sought to conduct a systematic review of the literature to evaluate the association between hemodynamic goals of therapy and patient outcomes. METHODS We conducted a comprehensive search of the literature to systematically review hemodynamic goals used in clinical trials in patients(More)
INTRODUCTION Randomized trials investigating neuromuscular blocking agents in adult acute respiratory distress syndrome (ARDS) have been inconclusive about effects on mortality, which is very high in this population. Uncertainty also exists about the associated risk of ICU-acquired weakness. METHODS We conducted a systematic review and meta-analysis. We(More)