Jonathan E. Millar

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Hypercarbic respiratory failure, occurring secondary to chronic lung disease, is a frequently encountered problem. These patients present a significant challenge to respiratory and critical care services, as many are unsuitable for mechanical ventilation and most have multiple comorbidities. Recently, noninvasive ventilation (NIV) has become established as(More)
Acute respiratory distress syndrome (ARDS) continues to have significant mortality and morbidity. The only intervention proven to reduce mortality is the use of lung-protective mechanical ventilation strategies, although such a strategy may lead to problematic hypercapnia. Extracorporeal carbon dioxide removal (ECCO₂R) devices allow uncoupling of(More)
BACKGROUND AND OBJECTIVE Venovenous extracorporeal membrane oxygenation (VV ECMO) and extracorporeal CO2 removal (ECCO2R) are increasingly used in the management of severe respiratory failure. With bleeding complications being one of the major risks of these techniques, our aim in this systematic review was to assess the available literature on acquired von(More)
Extracorporeal membrane oxygenation (ECMO) is a technology capable of providing short-term mechanical support to the heart, lungs or both. Over the last decade, the number of centres offering ECMO has grown rapidly. At the same time, the indications for its use have also been broadened. In part, this trend has been supported by advances in circuit design(More)
In contemporary reports, approximately 30% of patients with acute respiratory distress syndrome (ARDS) will die and up to 70% of survivors have persistent significant disability. Several interventions which limit injurious ventilation have been shown to reduce mortality, primarily: low-tidal volume ventilation, prone positioning, early neuromuscular(More)
The article by Lowe et al, illustrates how valuable lessons can be learnt from an individual hospital’s experience of two major incidents. A major incident is, thankfully a rare occurrence, so when one does take place, every opportunity should be taken to learn from it. This article gives a rare insight into how an analysis of these incidents can lead to(More)
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