Jonathan Dirlam

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In a previous report, a plasmid, pIG1, which contained the loading domain from the Streptomyces avermitilis polyketide synthase (PKS), promoters from Streptomyces coelicolor and the DEBS1-TE truncated PKS from Saccharopolyspora erythraea, was integrated into the S. erythraea chromosome, effectively replacing the natural erythromycin loading domain with the(More)
In the course of screening actinomycetes for novel antimicrobial substances, a new strain of Strepto-myceshygroscopicus was found to produce a new polyether antibiotic, CP-80,219 (1). This paper describes the isolation, properties and structure of 1, which is related to dianemycin (2).X) The fermentation of S. hygroscopicus sp. ATCC 53626 and isolation of(More)
In this study, we investigated two selection biases that may affect the obesity-mortality link over the life course: mortality selection and healthy participant effects. If these selection mechanisms are stronger among obese adults than among non-obese adults, they may contribute to the weakening obesity-mortality link over the life course. We used data(More)
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