Jonathan Denniss

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PURPOSE To evaluate the structure-function relationship between disc margin-based rim area (DM-RA) obtained with confocal scanning laser tomography (CSLT), Bruch's membrane opening-based horizontal rim width (BMO-HRW), minimum rim width (BMO-MRW), peripapillary retinal nerve fiber layer thickness (RNFLT) obtained with spectral-domain optical coherence(More)
PURPOSE To describe a software package (Discus) for investigating clinicians' subjective assessment of optic disc damage [diagnostic accuracy in detecting visual field (VF) damage, decision criteria, and agreement with a panel of experts] and to provide reference data from a group of expert observers. METHODS Optic disc images were selected from patients(More)
PURPOSE To determine whether the structure-function relationship in glaucoma can be strengthened by using more precise structural and functional measurements combined with individualized structure-function maps and custom sector selection on the optic nerve head (ONH). DESIGN Cross-sectional study. PARTICIPANTS One eye of each of 23 participants with(More)
PURPOSE To investigate the relationship between neuroretinal rim (NRR) differential light absorption (DLA, a measure of spectral absorption properties) and visual field (VF) sensitivity in primary open-angle glaucoma (POAG). METHODS Patients diagnosed with (n = 22) or suspected of having (n = 7) POAG were imaged with a multispectral system incorporating a(More)
PURPOSE We have developed customized maps that relate visual field and optic nerve head (ONH) regions according to individual anatomy. In this study, we aimed to determine feasible map resolution for research use, and to make a principled recommendation of sector size for clinical applications. METHODS Measurement variability in fovea-ONH distance and(More)
PURPOSE To present a computational model mapping visual field (VF) locations to optic nerve head (ONH) sectors accounting for individual ocular anatomy, and to describe the effects of anatomical variability on maps produced. METHODS A previous model that related retinal locations to ONH sectors was adapted to model eyes with varying axial length, ONH(More)
This study aimed to determine if response times gathered during perimetry can be exploited within a thresholding algorithm to improve the speed and accuracy of the test. Frequency of seeing (FoS) curves were measured at 24 locations across the central 30° of the visual field of 10 subjects using a Method of Constant Stimuli, with response times recorded for(More)
PURPOSE We evaluated variability and conviction in tracing paths of retinal nerve fiber bundles (RNFBs) in retinal images, and compared traced paths to a computational model that produces anatomically-customized structure-function maps. METHODS Ten retinal images were overlaid with 24-2 visual field locations. Eight clinicians and 6 naïve observers traced(More)
Purpose To demonstrate methods that enable visual field sensitivities to be compared with normative data without restriction to a fixed test pattern. Methods Healthy participants (n = 60, age 19-50) undertook microperimetry (MAIA-2) using 237 spatially dense locations up to 13° eccentricity. Surfaces were fit to the mean, variance, and 5th percentile(More)
PURPOSE To correlate in vivo spatial and spectral morphologic changes of short- to long-pulse 532 nm Nd:YAG retinal laser lesions using Fourier-domain optical coherence tomography (FD OCT), autofluorescence (AF), fluorescein angiography (FA), and multispectral imaging. METHODS Ten eyes with treatment-naive preproliferative or proliferative diabetic(More)