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In this study, a statistical model of cranium geometry for 0- to 3-month-old children was developed by analyzing 11 CT scans using a combination of principal component analysis and multivariate regression analysis. Radial basis function was used to morph the geometry of a baseline child head finite element (FE) model into models with geometries representing(More)
The pelves of the child dummies of the widely used Hybrid-III family are based on minimal data from children. Because an accurate pelvis design is critical for realistic assessments of belt restraint interactions, an analysis of medical imaging data was conducted to develop guidance for improved pelvis design. Three-dimensional polygonal meshes of the bony(More)
The objective of this study is to investigate the effects of obesity on occupant responses in frontal crashes using whole-body human finite element (FE) models representing occupants with different obesity levels. In this study, the geometry of THUMS 4 midsize male model was varied using mesh morphing techniques with target geometries defined by statistical(More)
A new prototype pregnant abdomen for the Hybrid III small-female ATD is being developed and has been evaluated in a series of component and whole-dummy tests. The new abdomen uses a fluid-filled silicone-rubber bladder to represent the human uterus at 30-weeks gestation, and incorporates anthropometry based on measurements of pregnant women in an automotive(More)
A finite element (FE) model with knee-thigh-hip (KTH) and lower-extremity muscles has been developed to study the potential effects of muscle tension on KTH injuries due to knee bolster loadings in frontal crashes. This model was created by remeshing the MADYMO human lower-extremity FE model to account for regional differences in cortical bone thickness,(More)
BACKGROUND Loosening of the prosthetic cup is the limiting factor in the service life of total hip prostheses (THPs). Despite effective culture methods, the detection of low-grade infection in patients with loose implants still presents a challenge. It is crucial to distinguish between "aseptic" loosening and loosening due to periprosthetic infection, so(More)
BACKGROUND The determination of Tumor M2 Pyruvate Kinase (Tumor M2-PK) in EDTA plasma has been described as a tumor marker in a variety of different tumor types. Since most GI tumors grow intraluminally, it appeared interesting to determine whether Tumor M2-PK is detectable in the feces of tumor patients. MATERIALS AND METHODS Measurements were performed(More)
The diagnostic value of pyruvate-kinase type tumor M2 (Tumor M2-PK) has been investigated in different tumors, and showed interesting results in cases of renal cancer, pancreatic cancer, lung cancer and some cases of gastric cancer. In this study we investigated EDTA-plasma of 68 patients with gastrointestinal cancer, 22 patients with inflammatory bowel(More)
Children, small female, elderly, and obese occupants are at greater risk of death and serious injuries in motor-vehicle crashes than the mid-size, young, male occupants. However, current injury assessment tools, including crash test dummies and finite element (FE) human models, generally do not account for different body shape and composition variations(More)
OBJECTIVE This project was undertaken to improve understanding of factors associated with adverse fetal outcomes of pregnant occupants involved in motor-vehicle crashes. STUDY DESIGN In-depth investigations of crashes involving 57 pregnant occupants were performed. Maternal and fetal injuries, restraint information, measures of external and internal(More)