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Spindles and slow waves are hallmarks of non-rapid eye movement sleep. Both these oscillations are markers of neuronal plasticity, and play a role in memory and cognition. Normal ageing is associated with spindle and slow wave decline and cognitive changes. The present study aimed to assess whether spindle and slow wave characteristics during a baseline(More)
Sleep spindles are a hallmark of NREM sleep. They result from a widespread thalamo-cortical loop and involve synchronous cortical networks that are still poorly understood. We investigated whether brain activity during spindles can be characterized by specific patterns of functional connectivity among cortical generators. For that purpose, we developed a(More)
Sleep slow waves (SWs) change considerably throughout normal aging. In humans, SWs are generated and propagate on a structural backbone of highly interconnected cortical regions that form most of the default mode network, such as the insula, cingulate cortices, temporal lobe, parietal lobe, and medial frontal lobe. Regions in this network undergo cortical(More)
The role of genome architecture in transcriptional regulation has become the focus of an increasing number of studies over the past decade. Chromatin organization can have a significant impact on gene expression by promoting or restricting the physical proximity between regulatory DNA elements. Given that any change in chromatin state has the potential to(More)
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