Jonathan C Bartko

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The minichromosome maintenance (MCM) family of proteins is conserved from archaea to humans and is required for assembly of pre-replication complexes (pre-RCs) to initiate DNA replication. MCM9 is an uncharacterized member of the eukaryotic MCM protein family that contains conserved ATP binding and hydrolysis motifs. We have identified a novel alternatively(More)
A cataract is a pathological condition characterized by the clouding of the normally clear eye lens brought about by deposition of crystallin proteins in the lens fiber cells. These protein aggregates reduce visual acuity by scattering or blocking incoming light. Chemical damage to proteins of the crystallin family, accumulated over a lifetime, leads to(More)
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