Jonathan Birns

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BACKGROUND It has been suggested that impaired cerebral autoregulation and vasodilatory capacity may play in role in the pathogenesis of the leukoaraiosis seen in small vessel disease. Adequate perfusion of the deep white matter of the brain depends on the relationships between blood pressure (BP), cerebral vasoreactivity and autoregulation. METHODS 24 h(More)
These abstracts are copied directly fromthe online submission system and edited for uniformity of format. Authors are invited and given at least a fortnight to notify the sub-editor of amendments. Background Ambulatory BP monitoring (ABPM) is used to identify white coat hypertension (WCH). Some individuals however have mean daytime BP >135/85 mmHg on ABPM(More)
OBJECTIVE To investigate whether the location and extent of the CT hyperdense artery sign (HAS) at presentation affects response to IV alteplase in the randomized controlled Third International Stroke Trial (IST-3). METHODS All prerandomization and follow-up (24-48 hours) CT brain scans in IST-3 were assessed for HAS presence, location, and extent by(More)
BACKGROUND Stroke is a clinical priority requiring early specialist assessment and treatment. A London (UK) stroke strategy was introduced in 2010, with Hyper Acute Stroke Units (HASUs) providing specialist and high dependency care. To support increased numbers of specialist staff, innovative multisite multiprofessional simulation training under a standard(More)
The differential effect of halothane on the characteristics of fast and slow components of vestibular nystagmus was investigated in rabbits. Eye movements were monitored using the "magnetic search coil" method and evaluated with the aid of a laboratory minicomputer. Low concentrations of halothane act preferentially on the fast component. There is a shift(More)
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