Jonathan Ashley

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QBIC (Query By Image Content) is a prototype software system for image retrieval developed at the IBM Almaden Research Center. It allows a user to query an image collection using features of image content – colors, textures, shapes, locations, and layout of images and image objects. For example, a user can query for images with a green background that(More)
Semantic versus nonsemantic information icture yourself as a fashion designer needing images of fabrics with a particular mixture of colors, a museum cataloger looking P for artifacts of a particular shape and textured pattern, or a movie producer needing a video clip of a red car-like object moving from right to left with the camera zooming. How do you(More)
In the continuing search for effective cancer treatments, we report the rational engineering of a multifunctional nanoparticle that combines traditional chemotherapy with cell targeting and anti-adhesion functionalities. Very late antigen-4 (VLA-4) mediated adhesion of multiple myeloma (MM) cells to bone marrow stroma confers MM cells with(More)
Nanomedicine, particularly liposomal drug delivery, has expanded considerably over the past few decades, and several liposomal drugs are already providing improved clinical outcomes. Liposomes have now progressed beyond simple, inert drug carriers and can be designed to be highly responsive in vivo, with active targeting, increased stealth, and controlled(More)
PEGylated liposomes are attractive pharmaceutical nanocarriers; however, literature reports of ligand-targeted nanoparticles have not consistently shown successful results. Here, we employed a multifaceted synthetic strategy to prepare peptide-targeted liposomal nanoparticles with high purity, reproducibility, and precisely controlled stoichiometry of(More)
Carfilzomib, a recently FDA-approved proteasome inhibitor, has remarkable anti-myeloma (MM) activity. However, its effectiveness is limited by associated severe side-effects, short circulation half-life, and limited solubility. Here, we report the engineering of liposomal carfilzomib nanoparticles to overcome these problems and enhance the therapeutic(More)