Jonathan Alunge Metuge

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BACKGROUND The lack of a safe and effective adult worm drug and the emergence of resistant animal parasite strains to the only recommended drug, the microfilaricide, ivermectin put many at risk of the devastating effects of the onchocerciasis. The present study was undertaken to investigate the acclaimed anti-Onchocerca activity of the roots/rhizomes of(More)
BACKGROUND Onchocerciasis caused by Onchocerca volvulus is the world's second leading infectious cause of blindness. There is currently no cure for the disease. Ivermectin, the current drug of choice is only microfilaricidal and suboptimal response to it is increasingly being reported. Thus, in contributing to the search for a cure, crude extracts and(More)
The aims of this investigation were to isolate active ingredients from the roots/rhizomes of Cyperus articulatus used as herbal medicine in Cameroon for the treatment of human onchocerciasis and to assess the efficacy of the metabolites on the Onchocerca worm. The antifilarial activity was evaluated in vitro on microfilariae (Mfs) and adult worms of the(More)
Onchocerciasis or river blindness is a parasitic disease of man, caused by the filarial worm Onchocerca volvulus. It afflicts an estimated 37 million people, among whom 300,000 are blind and an additional 500,000 are visually impaired. The only class of drug targets whose X-ray crystal structure has been solved is the glutathione transferases,(More)
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