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  • Juan Antonio Hernandez Ballesteros, Allan D. Jensen, +4 authors Jonathan A. Javitch
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2001 (First Publication: 3 August 2001)
  • The movements of transmembrane segments (TMs) 3 and 6 at the cytoplasmic side of the membrane play an important role in the activation of G-protein-coupled receptors. Here we provide evidence for theExpand
  • Jonathan A. Javitch, Robert J D'Amato, Stephen M. Strittmatter, Solomon H Snyder
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences…
  • 1985 (First Publication: 1 April 1985)
  • N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces neuropathological and clinical abnormalities in humans, monkeys, and mice that closely resemble idiopathic parkinsonism.Expand
  • Lei Shi, Matthias Quick, Yongfang Zhao, Harel Weinstein, Jonathan A. Javitch
  • Biology, Medicine
  • Molecular cell
  • 2008 (First Publication: 1 June 2008)
  • Eukaryotic neurotransmitter:sodium symporters (NSSs), targets for antidepressants and psychostimulants, terminate neurotransmission by sodium-driven reuptake. The crystal structure of LeuT(Aa), aExpand
  • Lei Shi, George Liapakis, Rui Xu, Frank Guarnieri, Juan Antonio Hernandez Ballesteros, Jonathan A. Javitch
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 2002 (First Publication: 25 October 2002)
  • In many rhodopsin-like G-protein-coupled receptors, agonist binding to a cluster of aromatic residues in TM6 may promote receptor activation by altering the configuration of the TM6 Pro-kink and byExpand
  • Christine Saunders, J V Ferrer, +7 authors Aurelio Galli
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences…
  • 2000 (First Publication: 6 June 2000)
  • The dopamine transporter (DAT) is a target of amphetamine (AMPH) and cocaine. These psychostimulants attenuate DAT clearance efficiency, thereby increasing synaptic dopamine (DA) levels. Re-uptakeExpand