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Additive value of amyloid-PET in routine cases of clinical dementia work-up after FDG-PET
TLDR
FBB-PET has a high additive value in establishing a final diagnosis in suspected dementia cases when prior investigations such as FDG-PET are inconclusive, predicting a considerable impact on patient management, especially in the light of upcoming disease-modifying therapies. Expand
Metabolic Correlates of Dopaminergic Loss in Dementia with Lewy Bodies
Striatal dopamine deficiency and metabolic changes are well‐known phenomena in dementia with Lewy bodies and can be quantified in vivo by 123I‐Ioflupane brain single‐photon emission computedExpand
Neuronal injury biomarkers for assessment of the individual cognitive reserve in clinically suspected Alzheimer's disease
TLDR
These findings suggest that subjects with higher cognitive reserve had accumulated more pathology, which subsequently caused a faster cognitive decline over time, and propose a biphasic reserve effect, with an initially protective phase followed by more rapid decompensation once the protection is overwhelmed. Expand
Clinical Routine FDG-PET Imaging of Suspected Progressive Supranuclear Palsy and Corticobasal Degeneration: A Gatekeeper for Subsequent Tau-PET Imaging?
TLDR
FDG-PET has high value in clinical routine evaluation of suspected T+APS, gaining satisfactory differential diagnosis in two thirds of the patients, and one third of patients would potentially profit from further evaluation by more specific radioligands. Expand
Cognitive reserve hypothesis in frontotemporal dementia: A FDG-PET study
TLDR
The educational level predicts left-temporal hypometabolism in FTD and the cognitive reserve hypothesis is also applicable for FTD. Expand