Jonas S. G. Silvander

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Keratin intermediate filament (IF) proteins are epithelial cell cytoskeletal components that provide structural stability and protection from cell stress, among other cellular and tissue-specific functions. Numerous human diseases are associated with IF gene mutations, but the function of keratins in the endocrine pancreas and their potential significance(More)
Catharina M. Alam, Jonas S. G. Silvander, Ebot N. Daniel, Guo-Zhong Tao, Sofie M. Kvarnström, Parvez Alam, M. Bishr Omary, Arno Hänninen and Diana M. Toivola* Department of Biosciences, Cell Biology, Åbo Akademi University, Tykistökatu 6A, FIN-20520 Turku, Finland Department of Surgery, Stanford University School of Medicine, Stanford, California, USA(More)
Keratins (K) are important for epithelial stress protection as evidenced by keratin mutations predisposing to human liver diseases and possibly inflammatory bowel diseases. A role for K8 in the colon is supported by the ulcerative colitis-phenotype with epithelial hyperproliferation and abnormal ion transport in K8-knockout (K8-/-) mice. The heterozygote(More)
Simple epithelial keratins (SEKs) are the cytoplasmic intermediate filament proteins of single-layered and glandular epithelial cells as found in the liver, pancreas, intestine, and lung. SEKs have broad cytoprotective functions, which are facilitated by dynamic posttranslational modifications and interaction with associated proteins. SEK filaments are(More)
Loss of the epithelial intermediate filament protein keratin 8 (K8) in murine β-cells leads to irregular insulin vesicles and decreased insulin levels. Because mitochondria are central in glucose-stimulated insulin secretion, the relationship between keratins and β-cell mitochondrial function and morphology was investigated. β-cells in murine K8 knockout(More)
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