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The biparietal diameter (BPD)/femur length ratio, nuchal skin thickening, and measured-to-expected femur length ratio have been suggested as sonographic predictors of Down syndrome. In an effort to validate these parameters, we compared their individual and combined prevalence in 22 fetuses with Down syndrome. Using our normative data, the sensitivity and(More)
BACKGROUND This study evaluates the association between high sensitivity troponin I (hsTnI) and T (hsTnT) in patients with suspected coronary artery disease (CAD) undergoing coronary computed tomography angiography (CCTA). METHODS Patients undergoing CCTA during routine clinical care were prospectively enrolled. CCTA was indicated by a low to intermediate(More)
BACKGROUND Coronary artery disease (CAD) is the most common reason for death in the western hemisphere. Therefore, a well-functioning risk-management has been established over the past decades with uprising interest in 'novel' biomarkers to predict adverse coronary events and detect patients with subclinical CAD. This review will focus on selected(More)
OBJECTIVE There is increasing evidence supporting the role of platelets in atherosclerotic vascular disease. The G-protein-coupled receptor P2Y12 is a central mediator of platelet activation and aggregation but has also been linked to platelet-independent vascular disease. Ticagrelor is an oral P2Y12 antagonist that is used as a standard treatment in(More)
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