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This study examined if individuals who are at increased risk for drowsy-driving because of obstructive sleep apnea syndrome (OSAS), have impairments in driving performance in the moments during microsleep episodes as opposed to during periods of wakefulness. Twenty-four licensed drivers diagnosed with OSAS based on standard clinical and polysomnographic(More)
Recent research has shown that depression in multiple sclerosis (MS) is associated with deficits on cognitively demanding tasks. One explanation for this relationship is that depressed MS patients may have reduced working memory capacity. The present study was designed to test this hypothesis. Depressed MS patients were compared with nondepressed MS(More)
A prospective study of 19 neurological soft signs in 44 male chronic schizophrenic patients and 29 matched control subjects revealed significantly more neurological abnormalities in the schizophrenic group. The schizophrenic patients were divided into paranoid and nonparanoid subtypes using the Tsuang-Winokur criteria. No significant differences emerged(More)
Because it is theorized that depression results in reduced available attentional capacity that, in turn, can explain the impaired performance on capacity-demanding tasks in depressed individuals, the authors predicted that multiple sclerosis (MS) patients with depressed mood would have difficulty with these types of tasks. Twenty depressed mood MS(More)
Because the cause and natural history of amaurosis fugax and ocular infarction are unknown in most younger patients, we reviewed the records of 83 patients who had become symptomatic before the age of 45. Cerebral transient ischemic attacks had occurred in 9 of these patients but no case of stroke was found. A striking feature of these patients was that 41%(More)
OBJECTIVE To determine the effects of obstructive sleep apnea (OSA) on visual vigilance during simulated automobile driving. METHODS Twenty-five drivers with OSA and 41 comparison drivers participated in an hour-long drive in a high-fidelity driving simulator. Drivers responded to light targets flashed at seven locations across the forward horizon.(More)
Modified leukotomies were performed on 5 patients with severe, incapacitating obsessional neurosis. Symptoms had been present for 6 or more years in all patients, and 3 had been ill for more than 20 years. All had received adequate trials of more conventional treatments before the leukotomy but had shown little response. At the time of follow-up, which(More)