Jon Thacker

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PURPOSE To investigate whether arterial spin labeling (ASL) MRI is sensitive to changes by pharmacologically induced vasodilation and vasoconstriction in rat kidneys. MATERIALS AND METHODS Changes in renal cortical blood flow in seven rats were induced by adenosine infusion (vasodilation) and L-NAME injection (vasoconstriction). All imaging studies were(More)
BACKGROUND The current clinical classification of chronic kidney disease (CKD) is not perfect and may be overestimating both the prevalence and the risk for progressive disease. Novel markers are being sought to identify those at risk of progression. This preliminary study evaluates the feasibility of magnetic resonance imaging based markers to identify(More)
OBJECTIVES The aims of this study were to investigate and validate quantitative susceptibility mapping (QSM) for lesional iron quantification in cerebral cavernous malformations (CCMs). MATERIALS AND METHODS Magnetic resonance imaging studies were performed in phantoms and 16 patients on a 3-T scanner. Susceptibility weighted imaging, QSM, and R2* maps(More)
INTRODUCTION Chronic kidney disease (CKD) is known to be associated with reduced renal blood flow. However, data to-date in humans is limited. METHODS In this study, non-invasive arterial spin labeling (ASL) MRI data was acquired in 33 patients with diabetes and stage-3 CKD, and 30 healthy controls. RESULTS A significantly lower renal blood flow both in(More)
OBJECTIVE The objective of this study was to evaluate the effects of potential renoprotective interventions such as the administration of N-acetylcysteine (NAC; antioxidant) and furosemide (diuretic) on intrarenal oxygenation as evaluated by blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) in combination with urinary neutrophil(More)
PURPOSE Blood oxygen level-dependent (BOLD) MRI has been effectively used to monitor changes in renal oxygenation. However, R2* (or T2*) is not specific to blood oxygenation and is dependent on other factors. This study investigates the use of a statistical model that takes these factors into account and maps BOLD MRI measurements to blood pO2. METHODS(More)
Non-Technical Loss (NTL) represents a major challenge when providing reliable electrical service in developing countries, where it often accounts for 11-15% of total generation capacity [1]. NTL is caused by a variety of factors such as theft, unmetered homes, and inability to pay, which at volume can lead to system instability, grid failure, and major(More)
Non-technical loss (NTL) represents a major challenge when providing reliable electrical service in developing countries, where it often accounts for 11-15% of total generation capacity [1]. NTL is caused by a variety of factors such as theft, unmetered homes, and inability to pay which at volume can lead to system instability, grid failure, and major(More)
OBJECTIVES The aim of this study was to determine a robust (sensitive and objective) method for analyzing renal blood oxygenation level-dependent magnetic resonance imaging data. MATERIALS AND METHODS Forty-seven subjects (30 with chronic kidney disease [CKD] and 17 controls) were imaged at baseline and after furosemide with a multiecho gradient recalled(More)
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