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Angiopoietin-1 Requires Oxidant Signaling through p47phox to Promote Endothelial Barrier Defense

• Chandra C. Ghosh, Aditi Mukherjee, Sascha A David, Katelyn E. Milam, Jon T. Hunter, Samir Parikh
• PloS one
• 2015

BACKGROUND Reactive oxygen species (ROS) are largely considered to be pathogenic to normal endothelial function in disease states such as sepsis. We hypothesized that Angiopoietin-1 (Angpt-1), an… (More)

Trophoblast mitochondrial function is impaired in preeclampsia and correlates negatively with the expression of soluble fms-like tyrosine kinase 1.

• Zsuzsanna K Zsengeller, Augustine Rajakumar, +4 authors S Ananth Karumanchi
• Pregnancy hypertension
• 2016

Preeclampsia is a common medical complication of pregnancy that is associated with significant morbidity and mortality to the mother and the baby. Extensive human epidemiological and experimental… (More)

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