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OBJECTIVE To examine the role of major parental and child diagnostic factors in predicting episodes of serious affective disorder in adolescents in a nonreferred sample. METHOD The sample included 139 youngsters (average age 14 years at enrollment) drawn from a health maintenance organization and evaluated at two points in time 4 years apart. Both parents(More)
OBJECTIVE DSM-IV subtypes anorexia nervosa by the presence or absence of bulimic symptoms. Assessing whether bulimic symptoms are related to the probability of recovery can provide justification for subtyping of anorexia. METHOD Two hundred twenty-five treatment-seeking women with anorexia and/or bulimia nervosa were interviewed every 3 months for up to 4(More)
OBJECTIVE This study explored the effects of parental affective disorder on offspring in a nonreferred health maintenance organization 4 years after initial examination. METHOD The sample, average age 18.5 years, included 91% of the 153 youngsters initially studied. The main instruments were structured diagnostic interviews scored according to criterion(More)
OBJECTIVES The aims of this pilot study were to determine the feasibility and scientific merit of coordinating a large-scale investigation of childhood sexual abuse (CSA) in outpatient-eating disordered women and to evaluate the usefulness and potential adverse effects of a semistructured trauma interview. METHOD The sample was randomly selected from(More)
Little is known about contacts in the spliceosome between proteins and intron nucleotides surrounding the pre-mRNA branch-site and their dynamics during splicing. We investigated protein-pre-mRNA interactions by UV-induced crosslinking of purified yeast B(act) spliceosomes formed on site-specifically labeled pre-mRNA, and analyzed their changes after(More)
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