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OBJECTIVE Our objective was to evaluate the published literature and reach a consensus on the treatment of patients with ACTH-dependent Cushing's syndrome, because there is no recent consensus on the management of this rare disorder. PARTICIPANTS Thirty-two leading endocrinologists, clinicians, and neurosurgeons with specific expertise in the management(More)
The cases of deafness presented here have been selected primarily to illustrate the degree to which the acoustic ganglion has degenerated in profound or total deafness. Examples of seven types of acquired diseases of the inner ear and one type of probable congenital degeneration of uncertain cause are given. The number of surviving ganglion cells in each(More)
A case of herpes zoster oticus is presented in which the lateral and superior semicircular canals of the labyrinth were affected unilaterally. The results of several electronystagmographic examinations are described and correlated with the patient's description of symptoms. This case study indicates that disease affecting the lateral semicircular canal is(More)
Temporal bone histopathology of 17 aged patients who had spontaneous and gradually progressive bilateral sensorineural hearing losses associated with aging was studied. Six cases in the present material showed the gradually sloping audiometric curve; nine cases, abrupt high tone hearing loss; and two cases, the flat audiometric curve. The most prominent(More)
We describe the histopathologic features of the inner ear in a 19-year-old girl with bilateral total deafness associated with Kearns-Sayre syndrome. The inner ear shows advanced degree of cochleo-saccular degeneration, with almost complete absence of the organ of Corti in all turns. The spiral ganglion shows a reduction of about 60% to 70% of cells, with(More)
  • E A Spiegel, F G Ebaugh, Formerly, Rupp, Charles, Associate +119 others
PREFACE I T MAY BE considered a healthy sign that among the over 5200 papers reviewed in this volume nearly one third (about 1600) deal with basic sciences; also that the number of papers devoted to organic neurology and allied disciplines (over 1800) somewhat exceeds the productivity in the field of psychiatry (nearly 1500 papers). The neurosurgeons(More)
Histological study of the temporal bones of an infant with the preauricular pit, cervical fistula, hearing loss syndrome revealed abnormalities in the middle ear, the vestibular system, and the cochlea. There is a gross bilateral abnormality in the form and relationship of the middle ear spaces, the middle cranial fossa and the inner ear. The horizontal(More)
The temporal bones of three cases of acoustic neurinoma are described to illustrate histopathological features of inner ear lesions due to chronic partial obstruction of blood circulation by the tumor in the internal auditory meatus. Degenerative changes in the inner ear due to acoustic neurinoma were evaluated and compared with changes in the opposite ear.(More)
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