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1. Voltage-gated whole cell Ca2+ currents have been investigated in olfactory bulb (OB) output neurons acutely isolated from neonatal rats. 2. Identification of OB output neurons, mitral or tufted cells, was based on morphology and size and validated by their retrograde labeling with rhodamine or Fast Blue. Of labeled neurons, 45% exhibited either phasic or(More)
We tested the common hypothesis that rotation on systemic injection of dopaminergic agents in rats with unilateral 6-hydroxydopamine lesions of the substantia nigra is attributable to unequal stimulation of dopamine receptors between the two striata. No rotation occurred when dopamine, apomorphine or amphetamine were injected into dorsal striatum or nucleus(More)
When the regional effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on brain dopamine uptake sites in C57 Black mice were studied using [3H]mazindol autoradiography, marked regional differences in effect were seen: the mesolimbic system was less affected than the nigrostriatal tract and within each system the effect was more severe in the(More)
Binding sites for calcitonin and calcitonin gene-related peptide are widely distributed in the central nervous system. In this study, binding of [(125)I]-alpha-rat calcitonin gene-related peptide and [(125)I]-salmon calcitonin in adjacent sections of rat brain revealed clearly distinct patterns of binding in most regions although in some restricted areas(More)
The distribution of binding sites for calcitonin gene-related peptide (CGRP) in rat brain were studied using in vitro autoradiography. In a radioreceptor assay using [125I]human calcitonin gene-related peptide as the radioligand, with cerebellar cortical membranes, rat calcitonin gene-related peptide had a binding affinity constant of 1.16 +/- 0.23 X 10(10)(More)
The nucleus of the horizontal limb of the diagonal band, a component of the basal forebrain magnocellular complex affected in Alzheimer type dementia, supplies centrifugal innervation to the olfactory bulb. We have tested the hypothesis that horizontal limb of the diagonal band lesions will interfere with olfactory memory in a simple olfactory test(More)
In response to stimulation of the deep layers of the superior colliculus (SC) in the rat, nigral neurons were antidromically activated (latency 0.5-1.5 msec). Effective stimulations were located in ipsi- or contralateral SC deep layers lying above the central gray (CG) or more laterally; nigro-collicular neurons are exclusively located in the pars(More)