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Prion protein (PrP), which is involved in the pathogenesis of scrapie, occurs in 2 forms. The form extracted from scrapie brain is protease resistant (PrP-res), whereas PrP from normal brain is protease sensitive (PrP-sen). This study examined whether PrP-res could be detected in brains of sheep with scrapie by immunohistochemistry (IHC). A suitable IHC(More)
We present the results of the timing and color analysis of more than two hundred RXTE/PCA observations of the bright black-hole transient GX 339–4 obtained during its 2002/2003 outburst. The color-intensity evolution of the system, coupled to the properties of its fast time variability, allow the identification of four separate states. Depending on the(More)
Subject headings: Black hole physics – line:profiles – relativity – X-rays:bursts ABSTRACT We report evidence for an Fe K α fluorescence line feature and disk reflection in the Very High, High, and Low State X-ray spectra of the galactic microquasar XTE J1748−288 during its June 1998 outburst. Spectral analyses are made on data gathered throughout the(More)
The properties of the orbit and the donor star in the high mass X-ray binary microquasar LS 5039 indicate that accretion processes should mainly occur via a radiatively driven wind. In such a scenario, significant X-ray variability would be expected due to the eccentricity of the orbit. The source has been observed at X-rays by several missions, although(More)
Subject headings: Black hole physics – relativity – stars: binaries – physical data and processes: accretion disks ABSTRACT Cool thermal emission components have recently been revealed in the X-ray spectra of a small number of ultra-luminous X-ray (ULX) sources with L X ≥ 10 40 erg/s in nearby galaxies. These components can be well fitted with accretion(More)
We have analyzed an XMM-Newton observation of the nearby spiral galaxy NGC 1313, which contains two " ultra-luminous " X-ray (ULX) sources. We measure isotropic luminosities of L X = 2.0 × 10 40 erg s −1 and L X = 6.6 × 10 39 erg s −1 for NGC 1313 X-1 and X-2 (0.2-10.0 keV, assuming a distance of 3.7 Mpc). The spectra statistically require soft and hard(More)
Some ultraluminous X-ray sources in nearby galaxies show soft components resembling thermal disc emission. Calculations based on blackbody emission then indicate that the accreting black holes at the centres of these discs have masses of 100s to 1000s M ⊙. Establishing the existence of such intermediate mass black holes is of considerable importance so the(More)
BACKGROUND The relative cognitive and behavioral effects of lamotrigine (LTG) and topiramate (TPM) are unclear. METHODS The authors directly compared the cognitive and behavioral effects of LTG and TPM in 47 healthy adults using a double-blind, randomized crossover design with two 12-week treatment periods. During each treatment condition, subjects were(More)
OBJECTIVE Clinicians monitor cognitive effects of drugs primarily by asking patients to describe their side effects. We examined the relationship of subjective perception of cognition to mood and objective cognitive performance in healthy volunteers and neurological patients. METHODS Three separate experiments used healthy adults treated with lamotrigine(More)
Ovine scrapie is a member of the transmissible spongiform encephalopathies (TSEs), a heterogeneous family of fatal neurologic disorders characterized by deposition of an abnormal isoform (prion protein [PrP] PrP-Sc) of a cellular sialoglycoprotein in neural tissue. PrP-Sc is detectable in some lymphoid tissues of infected sheep months or years before(More)