Jon Kieffer

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T cells play a pathogenic role in many inflammatory and certain malignant skin diseases, including psoriasis, atopic and allergic contact dermatitis, and cutaneous T-cell lymphoma. Memory T cells that infiltrate the skin express a unique skin-homing receptor called cutaneous lymphocyte-associated antigen (CLA), a carbohydrate epitope that facilitates the(More)
Selenocysteine is incorporated cotranslationally at UGA codons, normally read as stop codons, in several bacterial proteins and in the mammalian proteins glutathione peroxidase (GPX), selenoprotein P and Type I iodothyronine 5' deiodinase (5'DI). Previous analyses in bacteria have suggested that a stem-loop structure involving the UGA codon and adjacent(More)
The goal of this study was to determine the mechanisms by which dendritic cells (DCs) in blood could interact with endothelium, a prerequisite to extravasation into tissues. Our results indicate that DCs express both HECA-452-reactive and nonreactive isoforms of P-selectin glycoprotein ligand 1 (PSGL-1) and can tether and roll efficiently on E- and(More)
Whereas thyrotropin releasing hormone is rapidly and extensively degraded by plasma of adult rats, no appreciable loss of biological or immunological activity is caused by plasma from rats 4 or 16 days old. The plasma of neonatal rats does not appear to contain an inhibitor of thyrotropin releasing hormone peptidase or a peptidase with altered substrate(More)
A novel pan-tilt mechanism has been developed to support high-perfonnance active vision research at the AND. The mechanism is unique in that it features parallel .actuation and cable-drive transmission technology. This paper describes its design ,and reports on the experimental evaluation of its perfonnance. Results show that the design concepts are sound,(More)
Multirobot systems are becoming more and more significant in industrial, commercial and scientific applications including: plant maintenance, warehouse operation, space missions, operations in hazardous environments and military applications. Localised control has advantages over hierarchical control because the robots can be autonomous. The goals of this(More)
We have recently described a mouse pituitary tumor line which produces only the alpha-subunit of the glycoprotein hormones. This tumor line may be a useful animal model to study autonomous pituitary tumors which secrete only alpha-subunit. Our pure alpha-subunit producing tumor was derived from a thyrotropic tumor which secreted intact TSH as well as free(More)
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