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Synthesis and collagenase inhibition of new glycosides of aranciamycinone: the aglycon of the naturally occurring antibiotic aranciamycin.
Glycosides of aranciamycinone were prepared by glycosylation with sugar acetates and trimethylsilyl triflate in dichloromethane. Glycosides of the following sugars were prepared:Expand
  • 7
Inhibition of collagenase by aranciamycin and aranciamycin derivatives.
Aranciamycin (1), an anthracycline antibiotic, was found to be an inhibitor of Clostridium histolyticum collagenase, with an IC50 = 3.7 x 10(-7) M. Elastase and trypsin were not inhibited atExpand
  • 21
Temporal and Spatial Variability as Neglected Ecosystem Properties: Lessons Learned From 12 North American Ecosystems
Evaluating and monitoring the “health” of large-scale systems will require new and innovative approaches. One such approach is to look for ecological signals in the structure of ecologicalExpand
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Long-term field-pilot studies of enhanced reductive dechlorination.