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TMEM150C/Tentonin3 Is a Regulator of Mechano-gated Ion Channels
Functional interaction of TMEM150C with mechano-gated ion channels from different classes (Piezo2, Piezo1, and the potassium channel TREK-1) using two independent methods of mechanical stimulation is found to significantly prolongs the duration of the mechani-current produced by all three channels, decreases apparent activation threshold in Piezo 2, and induces persistent current inPiezo1. Expand
Molecular basis of tactile specialization in the duck bill
The molecular characterization of embryonic duck bill is presented, which is shown to contain a high density of mechanosensory corpuscles innervated by functional rapidly adapting trigeminal afferents, providing insights into the molecular basis of mechanotransduction in a tactile-specialist vertebrate. Expand
Investigating the Role of Nav1.5 in Somatosensory Mechanosensation
Biophysical characterization of duck Nav1.5 in vitro and in trigeminal neurons reveals key functional differences between the human and duck orthologs of Nav 1.5 and suggest a novel role for this channel in the sense of touch. Expand
Stretch-Gated Ion Channels in Neuronal Mechanoreceptors
Electrophysiological analysis showed that duck trigeminal neurons have an augmented ability to convert touch into excitation, presumably due to the properties of the resident stretch-sensitive ion channels, and functional properties of these channels were explored in vitro. Expand