Jolanthe Bednarczyk

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Limb edema is a common problem in both rehabilitation and acute care settings. In the past, attempts to determine an optimal management strategy for limb edema have been limited by the lack of accurate, noninvasive, rapid, clinical tools for quantifying limb volumes. The water displacement method is slow and difficult to use in the clinical setting.(More)
Morphine sulfate increased the incorporation of carbon-14-labeled tyrosine into labeled catecholamines in the mouse brain. Tolerance was manifested by a shift to the right in the dose-response curve for morphine after mice were treated repeatedly with morphine. Naloxone, a specific morphine antagonist, also shifted the dose-response curve for morphine to(More)
BACKGROUND Tacrolimus has a wide spectrum of adverse effects, including neurotoxic and vascular events. Vascular dysfunction due to interference of tacrolimus with mitochondrial function in endothelial cells may contribute to these adverse reactions. MATERIAL/METHODS We evaluated the impact of clinically relevant tacrolimus concentrations after 48 hours(More)
BACKGROUND AND PURPOSE Recently, there has been a trend for designers to reduce the weight of wheelchairs. Wheelchair performance is frequently evaluated in clinical as well as laboratory settings by kinematic motion analysis. The purpose of this study was to examine the effect of weight on the kinematics of wheelchair propulsion in nonathletic adults and(More)
For many reasons, persons with spinal cord injury (SCI) are classified according to a set of guidelines in which the term classification refers to a numeric value based on some selection of motor, sensory, and/or functional tests. The resulting classification is used as a means of quantifying the extent of neurological injury. Scales that focus on(More)
INTRODUCTION Although cyclosporine A (CSA) is considered to be an efficient immunosuppressive compound in transplantation, vascular side effects like arterial hypertension, neurologic complications and other adverse reactions occur. Interference of CSA with mitochondrial function may be responsible for these side effects. METHODS We evaluated the effect(More)
This study examined the kinematic features of wheelchair propulsion in two neurologically matched groups of adults and children with uncomplicated spinal cord injury. The average mass and age of the pediatric group was much smaller than the adult group (37.4kg and 11.3 years vs 68.5kg and 33.5 years). Each subject propelled his/her own chairs and new,(More)
Preeclampsia (PE) and hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome have been linked to congenital fetal disorders of mitochondrial fatty acid oxidation (FAO). Different incidences may argue for the association of noncongenital alterations of mitochondrial energy metabolism with PE/HELLP syndrome. We studied human umbilical vein(More)
AIM The aim of this study was to investigate the impact of gestational age on energy metabolism in human umbilical vein endothelial cells (HUVECs) of preterm and term neonates. METHODS Activities of respiratory chain (RC) complexes I-V, citrate synthase (CS), overall mitochondrial fatty acid oxidation (FAO), carnitine palmitoyltransferase 2 (CPT2),(More)
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