Jolanta Florczak

Learn More
Neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD), are accompanied by increased levels of 8-oxo-2'-deoxyguanosine (8-oxo2dG) and alterations in levels of homocysteine (Hcy), methionine (Met), and cysteine (Cys). Hcy may undergo remethylation due to involvement of MTHFR, MTR and MTHFD1 proteins. Present studies are(More)
PURPOSE To determine the architectural pattern and neuropeptide content of canine corneal innervation. METHODS Corneal nerve fibers in normal dog eyes were labeled immunohistochemically with antibodies against protein gene product (PGP)-9.5, calcitonin gene-related peptide (CGRP), substance P (SP), vasoactive intestinal polypeptide (VIP), and tyrosine(More)
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory loss and personality changes. Pathological hallmarks of AD are: deposition of amyloid plaques and neurofibrillary tangles in the brain, accompanied by neuronal and synaptic loss. The genetic background of AD is heterogeneous and strongly depends on the form of the(More)
A small number (1-5%) of Alzheimer's disease (AD) cases associated with the early-onset form of the disease (EOAD) appears to be transmitted as a pure genetic, autosomal dominant trait. To date, three genes responsible for familial EOAD have been identified in the human genome: amyloid precursor protein (APP), presenilin 1 (PS1), and presenilin 2 (PS2).(More)
Paroxysmal phenomena such as dystonia in multiple sclerosis (MS) have approximate incidence ranged between 3.8%-17%. These symptoms in MS may represent transient phenomena related to inflammation in acute plaques and probably are secondary to irritation of demyelinated axons by lymphokines. Paroxysmal dystonia can occur at any time during the course of MS,(More)
In the Province of Poznań on the point day Dec 31 1986 the prevalence of lateral amyotrophic sclerosis was found to be 1.9 per 100 thousand and the incidence in 1986 was 1.1 per 100 thousand. In relation to a similar study in 1965 these results are insufficient for accepting a change in the prevalence of amyotrophic lateral sclerosis in the last twenty(More)
  • 1