Jolanda Wittenberg

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Clinical guidelines are important means to improve quality of health care while limiting cost and supporting the medical staff. They are written as free text with tables and figures. Transforming them into a formal, computer-processable representation is a difficult task requiring both computer scientist skills and medical knowledge. To bridge this gap, we(More)
Translating clinical guidelines into formal models is beneficial in many ways, but expensive. The progress in medical knowledge requires clinical guidelines to be updated at relatively short intervals, leading to the term living guideline. This causes potentially expensive, frequent updates of the corresponding formal models. When performing these updates,(More)
Clinical guidelines are becoming more and more important as a means to improve the quality of care by supporting medical staff. Modelling guidelines in a computer-processable form is a prerequisite for various computer applications , to improve the quality of guidelines and to support their application. However , transforming the original text into a formal(More)
Diagnostic tests commonly are characterized by their true positive (sensitivity) and true negative (specificity) classification rates, which rely on a single decision threshold to classify a test result as positive. A more complete description of test accuracy is given by the receiver operating characteristic (ROC) curve, a graph of the false positive and(More)
It is by now widely accepted that medical guidelines can help to significantly improve the quality of medical care. Unfortunately, constructing the required medical guidelines is a very labour intensive and costly process. The cost of guideline construction would decrease if guidelines could be built from a set of building blocks that can be reused across(More)
Congenital AIDS is on the rise and will pose multiple problems to society and to health care workers in particular, as more infants develop the disorder. Differentiation of AIDS from infantile grief reactions is of critical importance, as infants at risk for AIDS lose their mothers who have AIDS. Team approaches are optimal and should include psychiatric(More)
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