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Enhancing hepatic glycolysis reduces obesity: differential effects on lipogenesis depend on site of glycolytic modulation.

• Chaodong Wu, Johnthomas E Kang, +5 authors Alex J. Lange
• Cell metabolism
• 2005

Reducing obesity requires an elevation of energy expenditure and/or a suppression of food intake. Here we show that enhancing hepatic glycolysis reduces body weight and adiposity in obese mice.… (More)

De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR.

• Johnthomas E Kang, Stephen J. Huddleston, Joanne M. Fraser, Alexander Khoruts
• Journal of leukocyte biology
• 2008

Although regulatory CD4+CD25+ forkhead box p3+ (Foxp3+) T cells (Tregs) are generally thought to arise in the thymus as a separate lineage of CD4 T cells, they can also be induced de novo in the… (More)

Induction of TGF-beta1 and TGF-beta1-dependent predominant Th17 differentiation by group A streptococcal infection.

• Beinan Wang, Thamotharampillai Dileepan, +4 authors Patrick P. Cleary
• Proceedings of the National Academy of Sciences…
• 2010

Recurrent group A Streptococcus (GAS) tonsillitis and associated autoimmune diseases indicate that the immune response to this organism can be ineffective and pathological. TGF-beta1 is recognized as… (More)

Reduction of hepatic glucose production as a therapeutic target in the treatment of diabetes.

• Chaodong Wu, David A Okar, Johnthomas E Kang, Alex J. Lange
• Current drug targets. Immune, endocrine and…
• 2005

There has been an alarming increase in the population diagnosed with diabetes worldwide. Although there is an ongoing debate as to the role of liver in the pathogenesis of diabetes, reduction of… (More)

Protein kinase C and receptor kinase gene expression in olfactory receptor neurons.

• Richard C. Bruch, Johnthomas E Kang, Michael Lane Moore, Kathryn F. Medler
• Journal of neurobiology
• 1997

Recent biochemical evidence indicates that protein kinase C (PKC) and G-protein-coupled receptor kinases (GRKs) are involved in olfactory signal termination and desensitization. The polymerase chain… (More)

Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies.

• Hongfeng Guo, Johnthomas E Kang, +12 authors Xianzheng Zhou
• Molecular therapy : the journal of the American…
• 2008

We have reported earlier that the non-viral Sleeping Beauty (SB) transposon system can mediate genomic integration and long-term reporter gene expression in human primary peripheral blood (PB) T… (More)

Stable engraftment of human microbiota into mice with a single oral gavage following antibiotic conditioning

• Christopher Staley, Thomas M Kaiser, +7 authors Alexander Khoruts
• Microbiome
• 2017

BACKGROUND Human microbiota-associated (HMA) animal models relying on germ-free recipient mice are being used to study the relationship between intestinal microbiota and human disease. However,… (More)

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