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Brugada syndrome is characterized by right bundle branch block pattern with ST-segment elevation in leads V(1) to V(3) and a propensity for sudden cardiac death due to ventricular arrhythmias. The arrhythmogenic substrate in Brugada syndrome may not be restricted to the ventricles, and atrial arrhythmias are being increasingly reported. Incidences of(More)
OBJECTIVE To investigate whether antidrug antibodies and/or drug non-trough levels predict the long-term treatment response in a large cohort of patients with rheumatoid arthritis (RA) treated with adalimumab or etanercept and to identify factors influencing antidrug antibody and drug levels to optimize future treatment decisions. METHODS A total of 331(More)
Initial acceleration and a subsequent deceleration of sinus rhythm following a ventricular ectopic beat with a compensatory pause has been termed heart rate turbulence (HRT). The changes in sinus rhythm are thought to be mediated by a baroreflex response to the lower stroke volume of the ectopic beat. HRT is vagally mediated and abolished by atropine,(More)
BACKGROUND Vitamin D may affect the severity of HCV-related liver disease. AIM To examine the association between serum vitamin D levels and advanced liver disease in a multiethnic US cohort of HCV patients, and account for dietary and supplemental intake. METHODS We measured serum 25-hydroxyvitamin D levels and used FibroSURE-ActiTest to assess hepatic(More)
Dual ventricular response to a single supraventricular impulse is an interesting possibility in the presence of dual atrioventricular nodal physiology. Double His bundle and ventricular responses to a single atrial impulse caused by a simultaneous fast and slow pathway conduction is the hallmark of this condition. One of the earliest descriptions of(More)
Various mental and social problems can negatively impact the quality of life and overall health in patients with implantable cardiac defibrillators (ICD). In this report, we review and summarize the main studies and research related to this topic. Depression, anxiety, panic attacks, stress and post-traumatic stress are the most common symptoms of(More)
Genetically engineered pacemakers could be a possible alternative to implantable electronic devices for the treatment of bradyarrhythmias. The strategies include upregulation of beta adrenergic receptors, conversion of myocytes into pacemaker cells and stem cell therapy. Pacemaker activity in adult ventricular myocytes is normally repressed by the inward(More)
OBJECTIVE To describe the contemporary features of coagulase-negative staphylococcal (CoNS) prosthetic valve endocarditis (PVE). DESIGN Observational study of prospectively collected data from a multinational cohort of patients with infective endocarditis. Patients with CoNS PVE were compared to patients with Staphylococcus aureus and viridans(More)