Johnnie M. Moore-Dotson

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Neurotransmitter release varies between neurons due to differences in presynaptic mechanisms such as Ca(2+) sensitivity and timing. Retinal rod bipolar cells respond to brief dim illumination with prolonged glutamate release that is tuned by the differential release of GABA and glycine from amacrine cells in the inner retina. To test if differences among(More)
The timing of neurotransmitter release from neurons can be modulated by many presynaptic mechanisms. The retina uses synaptic ribbons to mediate slow graded glutamate release from bipolar cells that carry photoreceptor inputs. However, many inhibitory amacrine cells, which modulate bipolar cell output, spike and do not have ribbons for graded release.(More)
PURPOSE Recent studies suggest that the neural retinal response to light is compromised in diabetes. Electroretinogram studies suggest that the dim light retinal rod pathway is especially susceptible to diabetic damage. The purpose of this study was to determine whether diabetes alters rod pathway signaling. METHODS Diabetes was induced in C57BL/6J mice(More)
Slow changes in Ca cause prolonged release from GABAergic retinal amacrine cells 1 2 Running head: Prolonged amacrine cell GABA release 3 4 5 Erika D. Eggers, Justin S. Klein and Johnnie M. Moore-Dotson 6 7 Departments of Physiology and Biomedical Engineering, University of Arizona, Tucson, AZ. 8 9 10 11 Corresponding author: 12 Erika D. Eggers 13(More)
Title: Different types of retinal inhibition have distinct neurotransmitter release properties 1 Running Title: Ca-buffering differentially affects amacrine cell release 2 Authors: Johnnie M. Moore-Dotson, Justin S. Klein, Reece E. Mazade, Erika D. Eggers 3 Department of Physiology, University of Arizona, Tucson, AZ 85724 4 Department of Biomedical(More)
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