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A pharmacologic target of G3139 in melanoma cells may be the mitochondrial VDAC.

• Johnathan C H Lai, Wenzhi Tan, Luba Benimetskaya, Paul Q Miller, Marco Colombini, C. A. Stein
• Proceedings of the National Academy of Sciences…
• 2006

G3139, an 18-mer phosphorothioate antisense oligonucleotide targeted to the initiation codon region of the Bcl-2 mRNA, can induce caspase-dependent apoptosis via the intrinsic mitochondrial pathway… (More)

Relative Bcl-2 independence of drug-induced cytotoxicity and resistance in 518A2 melanoma cells.

• Luba Benimetskaya, Johnathan C H Lai, +5 authors C. A. Stein
• Clinical cancer research : an official journal of…
• 2004

PURPOSE Inhibition of the function of Bcl-2 protein has been postulated to sensitize cells to cytotoxic chemotherapy. G3139 (Genasense) is a phosphorothioate anti-Bcl-2 antisense oligonucleotide, but… (More)

Antisense RNA down-regulation of bcl-2 expression in DU145 prostate cancer cells does not diminish the cytostatic effects of G3139 (Oblimersen).

• Anthony J Raffo, Johnathan C H Lai, +4 authors Luba Benimetskaya
• Clinical cancer research : an official journal of…
• 2004

PURPOSE Inhibition of the function of the bcl-2 protein has been postulated to sensitize cells to cytotoxic chemotherapy, and thus provides an attractive target for investigative therapies. G3139, a… (More)

Phosphorothioate oligodeoxynucleotides and G3139 induce apoptosis in 518A2 melanoma cells.

• Johnathan C H Lai, Luba Benimetskaya, +4 authors C. A. Stein
• Molecular cancer therapeutics
• 2005

In a previous study, we showed that G3139, an antisense phosphorothioate oligonucleotide that down-regulates the expression of Bcl-2 protein, did not cause chemosensitization of 518A2 melanoma cells.… (More)

Changes in gene expression induced by phosphorothioate oligodeoxynucleotides (including G3139) in PC3 prostate carcinoma cells are recapitulated at least in part by treatment with interferon-beta and…

• Luba Benimetskaya, Timo Wittenberger, +5 authors Volker Gekeler
• Clinical cancer research : an official journal of…
• 2004

PURPOSE G3139 is an antisense bcl-2 phosphorothioate oligodeoxyribonucleotide that is currently being evaluated in Phase III clinical trials in several human cancers. The aim of the present work was… (More)

Phosphorothioate oligonucleotides reduce mitochondrial outer membrane permeability to ADP.

• Wenzhi Tan, Johnathan C H Lai, Paul Q Miller, C. A. Stein, Marco Colombini
• American journal of physiology. Cell physiology
• 2007

G3139, an antisense Bcl-2 phosphorothioate oligodeoxyribonucleotide, induces apoptosis in melanoma and other cancer cells. This apoptosis happens before and in the absence of the downregulation of… (More)

Characterisation of plasmids encoding CTX-M-3 extended-spectrum beta-lactamase from Enterobacteriaceae isolated at a university hospital in Taiwan.

• Shu-Ying Liu, L H Su, Yu Liang Yeh, C C Chu, Johnathan C H Lai, C. H. Chiu
• International journal of antimicrobial agents
• 2007

CTX-M-3 is the most common extended-spectrum beta-lactamase produced by Enterobacteriaceae in Taiwan. The present study was conducted to characterise the genetic environment surrounding bla(CTX-M-3).… (More)

Protamine-fragment peptides fused to an SV40 nuclear localization signal deliver oligonucleotides that produce antisense effects in prostate and bladder carcinoma cells.

• Luba Benimetskaya, Nancy Guzzo-Pernell, Su-ting Liu, Johnathan C H Lai, Paul G Miller, C. A. Stein
• Bioconjugate chemistry
• 2002

The development of antisense technology has focused on improving methods for oligonucleotide delivery into cells. In the present work, we describe a novel strategy for oligonucleotide delivery based… (More)

Novel genetic aberrations in breast phyllodes tumours: comparison between prognostically distinct groups

• Wai Jin Tan, Johnathan C H Lai, +7 authors Puay Hoon Tan
• Breast Cancer Research and Treatment
• 2014

Phyllodes tumours of the breast are uncommon fibroepithelial neoplasms which pose management challenges due to difficulties in accurate prediction of clinical behaviour, as histological assessment… (More)

Single-Cell Measurements of Polyamidoamine Dendrimer Binding

• Johnathan C H Lai, Calin Yuan, James L. Thomas
• Annals of Biomedical Engineering
• 2002

The binding of fluorescein-labeled polyamidoamine dendritic polymers (dendrimers) to the surface of individual fibroblast cells has been quantitatively measured using confocal fluorescence… (More)

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