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Human pancreatic carcinoma xenograft models were developed from established MIA PaCa-2 and PANC-1 cell lines (ATCC, Rockville, MD). Tumors were maintained by serial trocar implantation in CD1 nu/nu mice, and attempts were made to test all drugs under optimal schedules at maximum tolerated doses. In both models, adriamycin, cisplatin, and 5-fluorouracil were… (More)
The impact of age on the enzymatic activities of adenosine metabolic enzymes, i.e., adenosine deaminase, adenosine kinase, cytosolic- and ecto-5'-nucleotidase have been assessed in the brain sleep/wake regulatory areas of young, intermediate and old rats (2, 12 and 24 months, respectively). There were significant spatial differences in the distribution of… (More)
In this panel we will explore two distinct approaches to reach transferability currently prevailing in the HCI community. We will discuss epistemological differences and the strengths and criticisms of each approach. Importantly, we will discuss the implications for HCI research practice given this diversity of methodological approaches.
Implantation of a defibrillator clearly extends life of heart patients. However, experience shows that this technique can also cause psychological difficulties, in some patients, making life sometimes unbearable. The risk of developing anxiety or depression is increased, causing a decrease in the quality of life. Feelings of helplessness, the… (More)