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Recently, the flagellin proteins of Methanococcus maripaludis were found to harbour an N-linked tetrasaccharide composed of N-acetylgalactosamine, di-acetylated glucuronic acid, an acetylated and acetamidino-modified mannuronic acid linked to threonine, and a novel terminal sugar(More)
Resveratrol is a plant polyphenol capable of exerting beneficial metabolic effects which are thought to be mediated in large by the activation of the NAD(+)-dependent protein deacetylase SIRT1. Although resveratrol has been claimed to be a bona fide SIRT1 activator using a peptide substrate (Fluor de Lys-SIRT1 peptide substrate), recent reports indicate(More)
In Archaea, the preflagellin peptidase (a type IV prepilin-like peptidase designated FlaK in Methanococcus voltae and Methanococcus maripaludis) is the enzyme that cleaves the N-terminal signal peptide from preflagellins. In methanogens and several other archaeal species, the typical flagellin signal peptide length is 11 to 12 amino acids, while in other(More)
A comprehensive understanding of the complex biodynamic response of the human fingers-hand-arm system may help researchers determine the causation of injuries arising from hand-transmitted vibration. This study theoretically demonstrates that the mechanical impedance (MI) in a hand power grip, as a measure of the biodynamic response of the system, can be(More)
In physiological loading conditions, the soft tissues in the hands and fingers are predominantly in compression. The goal of the present study was to characterize the nonlinear and time-dependent behavior of skin in compression. The pigskin samples used in the study were collected from five different animals. The compression tests were performed in confined(More)
The structure of pili from the archaeon Methanococcus maripaludis is unlike that of any bacterial pili. However, genetic analysis of the genes involved in the formation of these pili has been lacking until this study. Pili were isolated from a nonflagellated (ΔflaK) mutant and shown by sodium dodecyl sulfate-polyacrylamide gel electrophoresis to consist(More)
Extended exposure to mechanical vibration has been related to many vascular, sensorineural and musculoskeletal disorders of the hand-arm system, frequently termed 'hand-arm vibration syndrome' (HAVS). A two-dimensional, nonlinear finite element model of a fingertip is developed to study the stress and strain fields of the soft tissue under dynamic loading,(More)
Tactile performance of human fingertips is associated with activity of the nerve endings and sensitivity of the soft tissue within the fingertip to the static and dynamic skin indentation. The nerve endings in the fingertips sense the stress/strain states developed within the soft tissue, which are affected by the material properties of the tissues. The(More)
The reduction in vibrotactile sensitivity in the fingertip is assumed to be associated with the exposure of the tissues to repetitive, non-physiological strains during dynamic loading. Experimental results demonstrated that the magnitude of a vibration-induced temporary threshold shift is dependent upon the vibration frequency of both the exposure and(More)
Glycosylation is a posttranslational modification utilized in all three domains of life. Compared to eukaryotic and bacterial systems, knowledge of the archaeal processes involved in glycosylation is limited. Recently, Methanococcus voltae flagellin proteins were found to have an N-linked trisaccharide necessary for proper flagellum assembly. Current(More)