John Xun Yang

Learn More
A method is proposed for defining a probability distribution on an ensemble of protein conformations from a 2D NOE spectrum, while at the same time back-calculating the experimental spectrum from the ensemble. This enables one to assess the relative quality and significance of the conformations, and to test the consistency of the ensemble as a whole with(More)
A computational method is described that takes an initial estimate of the chemical shifts, line widths and scalar coupling constants for the protons in a molecule, and refines this estimate so as to improve the least-squares fit between an experimental COSY spectrum and the spectrum simulated from these parameters in the weak-coupling approximation. In(More)
A new computational method for simultaneously estimating all the proton-proton coupling constants in a molecule from COSY spectra [Yang, J.-X. and Havel, T.F. (1994) J. Biomol. NMR, 4, 807-826] is applied to experimental data from two polypeptides. The first of these is a cyclic hexapeptide denoted as VDA (-D-Ala1-Phe2-Trp3-Lys(Z)4-Val5-Phe6-), in(More)
Two-dimensional NMR spectra are rectangular arrays of real numbers, which are commonly regarded as digitized images to be analyzed visually. If one treats them instead as mathematical matrices, linear algebra techniques can also be used to extract valuable information from them. This matrix approach is greatly facilitated by means of a physically(More)
Passive microwave radiometer data over the ocean have been widely used, but data near coastlines or over lakes often cannot be used because of the large footprint with mixed signals from both land and water. For example, current standard Special Sensor Microwave Imager (SSM/I) products, including wind, water vapor, and precipitation , are typically(More)
—We develop methods of using boreal, temperate, and tropical forests as vicarious calibration sites for spaceborne microwave radiometers. The extended sites and improved calibration techniques enable examining warm-scene performances as a complement to cold scenes over the ocean, providing information about scan-dependent biases, detecting and correcting(More)
The Earth-scene brightness temperature (TB) seen by satellite radiometers is generally cold over the ocean due to low emissivity, warm over land with high emissivity, and with a large dynamic range dependent on frequency and polarization. Calibration at either cold or warm end cannot fully characterize the calibration dependence on the full TB dynamic(More)